Institute for Disorders for Impulse and Attention, Developmental Brain-Behaviour Laboratory, School of Psychology, University of Southampton, UK.
Brain Res. 2010 Mar 31;1322:134-43. doi: 10.1016/j.brainres.2010.01.057. Epub 2010 Feb 1.
Resting brain activity appears altered in Attention Deficit/Hyperactivity Disorder (ADHD). The default mode interference hypothesis (Sonuga-Barke and Castellanos, 2007) postulates that patterns of spontaneous very low frequency brain activity, typical of the resting brain, cause attention lapses in ADHD when they remain unattenuated following the transition from rest to active task performance. Here we test this hypothesis using DC-EEG.
DC-EEG recordings of very low frequency brain activity (<1.5Hz) were compared for 16 male children with ADHD and 16 healthy controls during both rest and active task performance (two choice reaction time task).
A previously identified very low frequency resting network of electrodes was replicated. At rest ADHD children showed less EEG power in very low frequency bands (i.e., .02-.2Hz). They also showed less attenuation of power at these frequency bands during rest-to-task transition. Reduced attenuation was associated with a number of measures of performance.
We confirmed the existence of altered very low frequency brain activity in ADHD. ADHD children may have deficits both in maintaining a resting brain when needed and 'protecting' an active brain from the intrusion of resting state brain activity.
在注意力缺陷多动障碍（ADHD）中，静息状态下的大脑活动似乎发生了改变。默认模式干扰假说（Sonuga-Barke 和 Castellanos，2007）假设，静息状态下自发的极低频率脑活动模式，是静息大脑的典型特征，当它们在从静息状态过渡到主动任务表现时仍然没有减弱时，会导致 ADHD 中的注意力不集中。在这里，我们使用 DC-EEG 来测试这一假设。
我们比较了 16 名 ADHD 男性儿童和 16 名健康对照组在静息和主动任务表现（二选一反应时间任务）期间的极低频率脑活动（<1.5Hz）的 DC-EEG 记录。
复制了先前确定的非常低频率的静息电极网络。在静息状态下，ADHD 儿童在非常低的频率带（即 0.02-0.2Hz）中显示出较少的 EEG 功率。他们在从静息到任务转换期间，这些频率带的功率衰减也较少。衰减减少与多项表现指标相关。
我们证实了 ADHD 中存在改变的非常低频率脑活动。ADHD 儿童可能在需要时维持静息大脑和“保护”活跃大脑免受静息状态大脑活动干扰方面存在缺陷。
