Dessein R, Rosenstiel P, Chamaillard M
INSERM U801, Lille, F-59019 France; University of Lille 2, Lille, F-59000, France.
Gastroenterol Clin Biol. 2009 Jun;33 Suppl 3:S131-6. doi: 10.1016/S0399-8320(09)73148-3.
Besides its role in repelling enteropathogenic infections, the gastrointestinal tract is in intimate contact with commensal microbiota. Tremendous advances have been made in determining the pivotal role of the microbiota in both tissue homeostasis and metabolism, as well as in the initiation and maintenance of inflammatory lesions in inflammatory bowel diseases. A better understanding of human gut microbiota could provide innovative targets for treating and/or curing such common immunopathologies of the gastrointestinal tract.
除了在抵御肠道致病性感染方面发挥作用外，胃肠道还与共生微生物群密切接触。在确定微生物群在组织稳态和新陈代谢以及炎症性肠病中炎症病变的起始和维持方面的关键作用方面已经取得了巨大进展。更好地了解人类肠道微生物群可以为治疗和/或治愈这种常见的胃肠道免疫病理提供创新靶点。
