Henderson N, Stanescu V, Cauchoix J
Institut de Recherche sur les Maladies du Squelette, Berke-sur-Mer, France.
Spine (Phila Pa 1976). 1991 Feb;16(2):203-8.
The nucleolytic action of chondroitinase ABC was studied by the use of rabbit lumbar intervertebral discs. The injection of one unit of enzyme results in necrosis of the nucleus pulposus. Radiologic, histologic, and biochemical changes were evident in discs studied 2 days after injection, and consistent nucleolysis was seen in those studied after 6 days. These results show that chondroitinase ABC deserves further evaluation as a possible chemonucleolytic enzyme.
利用兔腰椎间盘研究了软骨素酶ABC的核酸分解作用。注射一个单位的该酶会导致髓核坏死。在注射后2天研究的椎间盘中，放射学、组织学和生物化学变化明显，而在注射后6天研究的椎间盘中则出现了持续的核酸溶解现象。这些结果表明，软骨素酶ABC作为一种可能的化学髓核溶解酶值得进一步评估。
