Bae Won C, Masuda Koichi
Department of Radiology, University of California San Diego, San Diego, CA 92103-8226, USA.
Orthop Clin North Am. 2011 Oct;42(4):585-601, ix. doi: 10.1016/j.ocl.2011.07.004.
Intervertebral disks are biologically regulated by the maintenance of a balance between the anabolic and catabolic activities of disk cells. Therapeutic agents, initially evaluated using in vitro studies on disk cells and explants, have been used as intradiscal injections in preclinical settings to test in vivo efficacy. These include anabolic growth factors, other biostimulatory agents, and antagonistic agents against matrix-degrading enzymes and cytokines. Additional work is needed to identify patient populations, using methods such as MRI, and to better understand the mechanism of healing. Clinical trials are underway for a few of these agents and other promising candidates are on the horizon.
椎间盘通过维持椎间盘细胞合成代谢和分解代谢活动之间的平衡而受到生物学调节。最初在椎间盘细胞和外植体的体外研究中评估的治疗剂，已在临床前环境中用作椎间盘内注射以测试体内疗效。这些包括合成代谢生长因子、其他生物刺激剂以及针对基质降解酶和细胞因子的拮抗剂。需要开展更多工作，利用MRI等方法确定患者群体，并更好地了解愈合机制。其中一些药物正在进行临床试验，其他有前景的候选药物也即将出现。
