Department of Materials Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
Biomaterials. 2010 Apr;31(12):3274-80. doi: 10.1016/j.biomaterials.2010.01.026. Epub 2010 Feb 1.
We synthesized silicone hydrogels from 2-methacryloyloxyethyl phosphorylcholine (MPC) and bis(trimethylsilyloxy)methylsilylpropyl glycerol methacrylate (SiMA) using two methods: random copolymerization with a small amount of cross-linker (P(SiMA-co-MPC)) and construction of an interpenetration network (IPN) structure composed of cross-linked poly(MPC)(PMPC) chains and cross-linked poly(SiMA)(PSiMA) chains (PSiMA-ipn-PMPC). The polymerization was carried out by photoreaction. The surface hydrophilicity and water absorbability of P(SiMA-co-MPC) increased with an increase in the MPC unit composition. On the other hand, in the case of PSiMA-ipn-PMPC, a super-hydrophilic surface was obtained by the surface enrichment of MPC units. The optical and mechanical properties of PSiMA-ipn-PMPC are suitable for use as a material for preparing contact lenses. In addition, the oxygen permeability of PSiMA-ipn-PMPC remains high because of the PSiMA chains. The MPC units at the surface of the hydrogels reduce protein adsorption effectively. From these results for PSiMA-ipn-PMPC, we confirmed that it has the potential for application to silicone hydrogel contact lenses.
我们使用两种方法，从 2-甲基丙烯酰氧乙基磷酸胆碱（MPC）和双（三甲硅基氧基）甲基硅基丙基甘油甲基丙烯酸酯（SiMA）合成硅水凝胶：少量交联剂的随机共聚（P（SiMA-co-MPC））和由交联聚（MPC）（PMPC）链和交联聚（SiMA）（PSiMA）链组成的互穿网络（IPN）结构的构建（PSiMA-ipn-PMPC）。聚合通过光反应进行。P（SiMA-co-MPC）的表面亲水性和吸水性随着 MPC 单元组成的增加而增加。另一方面，在 PSiMA-ipn-PMPC 的情况下，通过 MPC 单元的表面富集获得超亲水表面。PSiMA-ipn-PMPC 的光学和机械性能适合用作制备隐形眼镜的材料。此外，由于 PSiMA 链，PSiMA-ipn-PMPC 的氧气透过率仍然很高。水凝胶表面的 MPC 单元可以有效减少蛋白质吸附。从 PSiMA-ipn-PMPC 的这些结果来看，我们证实它具有应用于硅水凝胶隐形眼镜的潜力。
