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年轻人饮酒与高血压事件的关系:来自年轻人冠状动脉风险发展研究的 20 年随访结果。

Alcohol consumption in young adults and incident hypertension: 20-year follow-up from the Coronary Artery Risk Development in Young Adults Study.

机构信息

University of Alabama at Birmingham,Birmingham, Alabama 35294-4410, USA.

出版信息

Am J Epidemiol. 2010 Mar 1;171(5):532-9. doi: 10.1093/aje/kwp417. Epub 2010 Jan 29.

Abstract

The relation between alcohol consumption and incident hypertension is unclear, and most observational studies have not accounted for socioeconomic factors. This study examined the association between alcohol consumption in a diverse group of young adults and incident hypertension over 20 years. Participants (n = 4,711) were from the Coronary Artery Risk Development in Young Adults Study cohort, recruited in 1985 (aged 18-30 years) from Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California. The 20-year incidence of hypertension for never, former, light, moderate, and at-risk drinkers was 25.1%, 31.8%, 20.9%, 22.2%, and 18.8%, respectively (P < 0.001). Race, gender, age, family history of hypertension, body mass index, income, education, and difficulty paying for basics and medical care were associated with hypertension. Adjustment using Cox proportional hazard models revealed no association between baseline alcohol consumption and incident hypertension, except among European-American women in whom any current alcohol consumption was associated with lower risk of incident hypertension. The lack of association between alcohol and hypertension in the majority of this socioeconomically diverse cohort is not definitive. Future studies should include social factors, such as income and education, and consider additional characteristics that may modify or confound associations between alcohol and blood pressure.

摘要

饮酒与高血压事件之间的关系尚不清楚,大多数观察性研究都没有考虑到社会经济因素。本研究在一个多样化的年轻成年人群体中,考察了饮酒与 20 多年来高血压事件之间的关联。参与者(n=4711)来自于冠状动脉风险发展中的年轻人研究队列,于 1985 年(年龄 18-30 岁)在阿拉巴马州伯明翰、伊利诺伊州芝加哥、明尼苏达州明尼阿波利斯和加利福尼亚州奥克兰招募。从不饮酒者、前饮酒者、轻度饮酒者、中度饮酒者和有风险饮酒者的高血压 20 年发生率分别为 25.1%、31.8%、20.9%、22.2%和 18.8%(P<0.001)。种族、性别、年龄、高血压家族史、体重指数、收入、教育程度以及支付基本生活费用和医疗费用的困难程度均与高血压相关。使用 Cox 比例风险模型进行调整后,除了在欧洲裔美国女性中,任何当前饮酒都与较低的高血压事件风险相关外,基线饮酒与高血压事件之间没有关联。在这个社会经济多样化的队列中,大多数人饮酒与高血压之间缺乏关联并不是定论。未来的研究应包括社会因素,如收入和教育程度,并考虑其他可能改变或混淆饮酒与血压之间关联的特征。

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