Greci Valentina, Stefanello Damiano, Di Giancamillo Mauro, Mortellaro Carlo M
Department of Veterinary Clinical Sciences, Division of Veterinary Surgery, School of Veterinary Medicine, University of Milan, Italy.
Can Vet J. 2009 Nov;50(11):1191-4.
Three dogs diagnosed with aspergillosis developed sinonasal tumors several months after successful treatment with topical clotrimazole solution. Chronic rhinosinusitis was also detected in all cases prior to diagnosis of sinonasal tumors. The inflammatory response to Aspergillus, clotrimazole treatment, and chronic inflammation after treatment are discussed as possible neoplastic promoting factors.
三只被诊断患有曲霉病的狗在用克霉唑溶液局部成功治疗数月后出现了鼻窦肿瘤。在鼻窦肿瘤诊断之前,所有病例均检测到慢性鼻窦炎。本文讨论了对曲霉的炎症反应、克霉唑治疗以及治疗后的慢性炎症作为可能的肿瘤促进因素。