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莱姆病表现为亚急性横贯性脊髓炎。

Lyme disease presenting as subacute transverse myelitis.

机构信息

Department of Neurology, Cukurova University School of Medicine, Adana, Turkey.

出版信息

Acta Neurol Belg. 2009 Dec;109(4):326-9.

PMID:20120216
Abstract

Lyme disease (borreliosis) is a systemic illness resulting from infection with the spirochete Borrelia burgdorferi. It is transmitted to humans by the bites of infected ticks belonging to several species of the genus Ixodes. After the bacteria enter the body via the dermis, most patients develop the early, localised form of Lyme disease, which is characterised by erythema migrans and influenza-like symptoms. This disease may also affect the heart, nervous system and joints. The neurological findings of this disease may include peripheral and central nervous system signs. A 21-year-old woman attended a family medicine outpatient clinic complaining of unexplained pain and muscle power loss in her lower extremities. The problem had started in her right leg 3 months earlier and worsened in the last week. She had a neurology consultation and was hospitalised. Her neurological examination revealed bilateral facial paralysis and sensory impairment. Immunoglobulin M antibody to B. burgdorferi was positive on Western blotting in both serum and cerebrospinal fluid. The patient was diagnosed with subacute neuroborreliosis and treated.

摘要

莱姆病(波状热)是一种全身性疾病,由感染伯氏疏螺旋体引起。它通过感染几种硬蜱属的蜱叮咬传播给人类。细菌通过真皮进入人体后,大多数患者会出现早期局部莱姆病,其特征是游走性红斑和流感样症状。这种疾病还可能影响心脏、神经系统和关节。这种疾病的神经系统表现可能包括周围和中枢神经系统体征。一名 21 岁的女性因下肢不明原因疼痛和肌肉无力到家庭医学门诊就诊。问题始于她的右腿,3 个月前开始,并在最后一周恶化。她进行了神经科会诊并住院。她的神经系统检查显示双侧面瘫和感觉障碍。血清和脑脊液的 Western blot 均显示免疫球蛋白 M 抗体对 B. burgdorferi 呈阳性。该患者被诊断为亚急性神经莱姆病并接受治疗。

相似文献

1
Lyme disease presenting as subacute transverse myelitis.莱姆病表现为亚急性横贯性脊髓炎。
Acta Neurol Belg. 2009 Dec;109(4):326-9.
2
[Early diagnosis of Lyme borreliosis].[莱姆病的早期诊断]
MMW Fortschr Med. 2006 Jun 22;148(25):32, 34, 36.
3
[Guideline 'Lyme borreliosis'].[《莱姆病诊疗指南》]
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Cerebrospinal fluid findings in patients with symptoms suggesting chronic Lyme borreliosis.有提示慢性莱姆病伯氏疏螺旋体感染症状患者的脑脊液检查结果
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[Lyme borreliosis in adults].[成人莱姆病]
Tidsskr Nor Laegeforen. 2008 May 15;128(10):1175-8.
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[Clinical characteristics of Lyme disease in 12 cases].12例莱姆病的临床特征
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Infection and musculoskeletal conditions: Lyme borreliosis.感染与肌肉骨骼疾病:莱姆病。
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Temporomandibular joint involvement caused by Borrelia Burgdorferi.由伯氏疏螺旋体引起的颞下颌关节受累。
J Craniomaxillofac Surg. 2007 Dec;35(8):397-400. doi: 10.1016/j.jcms.2007.06.003. Epub 2007 Oct 17.
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Orbital myositis associated with Borrelia burgdorferi (Lyme disease) infection.与伯氏疏螺旋体(莱姆病)感染相关的眼眶肌炎。
Ophthalmology. 2004 May;111(5):1023-8. doi: 10.1016/j.ophtha.2003.08.032.
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[Diagnosis and treatment of Lyme arthritis].[莱姆关节炎的诊断与治疗]
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引用本文的文献

1
Rare case of acute transverse myelitis associated with Lyme neuroborreliosis.莱姆病性神经伯氏疏螺旋体病相关的急性横贯性脊髓炎罕见病例。
IDCases. 2022 Jan 24;27:e01422. doi: 10.1016/j.idcr.2022.e01422. eCollection 2022.
2
Acute transverse myelitis - A rare clinical manifestation of Lyme neuroborreliosis.急性横贯性脊髓炎——莱姆病性神经伯氏疏螺旋体病的一种罕见临床表现。
IDCases. 2018 Dec 29;15:e00479. doi: 10.1016/j.idcr.2018.e00479. eCollection 2019.
3
Inflammation in the pathogenesis of lyme neuroborreliosis.莱姆病神经螺旋体病发病机制中的炎症
Am J Pathol. 2015 May;185(5):1344-60. doi: 10.1016/j.ajpath.2015.01.024. Epub 2015 Apr 16.
4
Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain.细胞因子和趋化因子在神经炎症、神经退行性变和神经病理性疼痛的交汇点。
Mediators Inflamm. 2013;2013:480739. doi: 10.1155/2013/480739. Epub 2013 Aug 12.
5
The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia.莱姆病螺旋体伯氏疏螺旋体诱导背根神经节细胞炎症和细胞凋亡。
J Neuroinflammation. 2013 Jul 18;10:88. doi: 10.1186/1742-2094-10-88.
6
A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi.炎症在介导莱姆病螺旋体伯氏疏螺旋体诱导的少突胶质细胞凋亡中的可能作用。
J Neuroinflammation. 2012 Apr 23;9:72. doi: 10.1186/1742-2094-9-72.