Sochaczewska Diana, Czeszyńska Maria Beata, Konefał Halina, Elster Tomasz, Baryła-Pankiewicz Elzbieta
Klinika Neonatologii, Pomorskiej Akademii Medycznej w Szczecinie.
Ginekol Pol. 2009 Dec;80(12):920-6.
To determine the relationship between cord blood cotinine levels and some markers of perinatal hypoxia such as cord blood erythropoietin levels, parameters of umbilical arterial blood gas analysis and Apgar scores.
150 women with uncomplicated, healthy singleton pregnancies were assessed by means of a patient questionnaire. Neonates born by the examined pregnant women were divided into 3 groups according to recorded maternal smoking status--active smoking: n = 51, passive smoking: n = 49, non smoking: n = 50. Immediately after birth umbilical venous (for cotinine and erythropoietin levels) and arterial blood (for pH, pO2, pCO2, BE) were collected.
Cotinine levels were significantly higher (p < 0.00001) in active smoking group (Me = 19.3 ng/ml) than in passive smoking (Me = 0.75 ng/ml) and non smoking (Me = 0.72 ng/ml) ones. Cord blood erythropoietin, pH values and 1, 3 and 5-minute Apgar scores did not differ significantly between the study groups. No significant correlation between cotinine and erythropoietin, pH and Apgar scores results in all study material and in the compared groups was found.
No correlation between cord blood cotinine and erythropoietin levels was detected. Cord blood cotinine concentration does not influence the condition of the newborn assessed by Apgar scores and umbilical arterial blood gas analysis.
确定脐血可替宁水平与围产期缺氧的一些标志物之间的关系，如脐血促红细胞生成素水平、脐动脉血气分析参数和阿氏评分。
通过患者问卷对150例单胎健康妊娠且无并发症的孕妇进行评估。根据记录的母亲吸烟状况，将受检孕妇所生新生儿分为3组——主动吸烟组：n = 51，被动吸烟组：n = 49，非吸烟组：n = 50。出生后立即采集脐静脉血（用于检测可替宁和促红细胞生成素水平）和动脉血（用于检测pH值、pO2、pCO2、碱剩余）。
主动吸烟组的可替宁水平（中位数 = 19.3 ng/ml）显著高于被动吸烟组（中位数 = 0.75 ng/ml）和非吸烟组（中位数 = 0.72 ng/ml）（p < 0.00001）。研究组之间的脐血促红细胞生成素、pH值以及1、3和5分钟阿氏评分无显著差异。在所有研究材料以及比较组中，未发现可替宁与促红细胞生成素、pH值和阿氏评分结果之间存在显著相关性。
未检测到脐血可替宁与促红细胞生成素水平之间存在相关性。脐血可替宁浓度不影响通过阿氏评分和脐动脉血气分析评估的新生儿状况。
