Clinic of Gynecology and Obstetrics, Clinical Centre of Montenegro, Podgorica, Montenegro.
Oxid Med Cell Longev. 2010 May-Jun;3(3):214-8. doi: 10.4161/oxim.3.3.12070.
Our aim was to investigate the relation between fetal distress and oxidative stress. Fetal distress was associated with increased concentration of superoxide in the fetal blood and with significant increase of the level of H2O2 in both maternal and fetal blood. The activity of superoxide dismutase was increased roughly sixfold (p<0.01) in the maternal (7330 +/- 2240 U/g of hemoglobin in controls (C) and 36811 +/- 16862 U/g in fetal distress (FD)) and fetal blood (C: 5930 +/- 2641 U/g; FD: 41912 +/- 17133 U/g). In contrast, fetal distress was related to a considerable decrease of catalase activity in both maternal (C: 26011 +/- 8811 U/g; FD: 7212 +/- 1270 U/g) and fetal blood (C: 37194 +/- 9191 U/g; FD: 6173 +/- 1965 U/g). From this we concluded that in fetal distress, the maternal and fetal bloods are exposed to superoxide- and H2O2-mediated oxidative stress, which could be initiated by hypoxic conditions in the fetal blood and placenta. A tremendous increase/decrease of the activities of superoxide dismutase/catalase in the blood of women bearing a distressed fetus in comparison to healthy subjects implies that the assessment of superoxide dismutase/catalase activity could be of use for establishing a timely and accurate ante- or intrapartum diagnosis of fetal distress.
我们的目的是研究胎儿窘迫与氧化应激之间的关系。胎儿窘迫与胎儿血液中超氧化物浓度的增加以及母血和胎血中 H2O2 水平的显著升高有关。超氧化物歧化酶的活性在母体血液中增加了约六倍（p<0.01）（对照组（C）为 7330 +/- 2240 U/g 血红蛋白，胎儿窘迫（FD）为 36811 +/- 16862 U/g）和胎血（C：5930 +/- 2641 U/g；FD：41912 +/- 17133 U/g）。相比之下，胎儿窘迫与母体（C：26011 +/- 8811 U/g；FD：7212 +/- 1270 U/g）和胎血（C：37194 +/- 9191 U/g；FD：6173 +/- 1965 U/g）中过氧化氢酶活性的显著降低有关。由此我们得出结论，在胎儿窘迫中，母体和胎血都受到超氧化物和 H2O2 介导的氧化应激的影响，这种应激可能是由胎儿血液和胎盘中的缺氧条件引发的。与健康受试者相比，携带有窘迫胎儿的妇女血液中超氧化物歧化酶/过氧化氢酶活性的显著增加/减少表明，评估超氧化物歧化酶/过氧化氢酶活性可能有助于及时准确地进行产前或产时胎儿窘迫的诊断。
