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Milk mysteries: Why are women who exclusively breast-feed less likely to transmit HIV during breast-feeding?

作者信息

Kuhn Louise

机构信息

Gertrude H. Sergievsky Center, Department of Epidemiology, Columbia University, New York, New York 10032, USA.

出版信息

Clin Infect Dis. 2010 Mar 1;50(5):770-2. doi: 10.1086/650536.

DOI:10.1086/650536
PMID:20121425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2843095/
Abstract
摘要

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Milk mysteries: Why are women who exclusively breast-feed less likely to transmit HIV during breast-feeding?乳汁之谜:为何纯母乳喂养的女性在哺乳期传播艾滋病毒的可能性较小?
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Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis.对 HIV-1 env 序列的遗传分析表明,母乳中存在有限的分隔现象,并提示在乳腺炎时,乳腺内的病毒复制增加。
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Breast milk and gut microbiota in African mothers and infants from an area of high HIV prevalence.高 HIV 流行地区非洲母婴的母乳和肠道微生物群。
PLoS One. 2013 Nov 26;8(11):e80299. doi: 10.1371/journal.pone.0080299. eCollection 2013.
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Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis.单次奈韦拉平预防给药后母乳中奈韦拉平耐药的 HIV-1 变异体的克隆扩增和母婴传播。
Retrovirology. 2013 Aug 14;10:88. doi: 10.1186/1742-4690-10-88.
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本文引用的文献

1
Associations between breast milk viral load, mastitis, exclusive breast-feeding, and postnatal transmission of HIV.母乳病毒载量、乳腺炎、纯母乳喂养与 HIV 产后传播之间的关系。
Clin Infect Dis. 2010 Mar 1;50(5):762-9. doi: 10.1086/650535.
2
High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission.母乳中高浓度的白细胞介素15与预防产后HIV传播有关。
J Infect Dis. 2009 Nov 15;200(10):1498-502. doi: 10.1086/644603.
3
Postnatal HIV-1 transmission after cessation of infant extended antiretroviral prophylaxis and effect of maternal highly active antiretroviral therapy.婴儿延长抗逆转录病毒预防措施停止后的产后HIV-1传播及母亲高效抗逆转录病毒治疗的效果
J Infect Dis. 2009 Nov 15;200(10):1490-7. doi: 10.1086/644598.
4
Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission.延长抗逆转录病毒预防措施以减少母乳中HIV-1的传播。
N Engl J Med. 2008 Jul 10;359(2):119-29. doi: 10.1056/NEJMoa0801941. Epub 2008 Jun 4.
5
Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first 4 months of breast-feeding.HIV阳性母亲在母乳喂养前4个月期间母乳中HIV脱落及钠升高的时间和横向动态变化。
J Acquir Immune Defic Syndr. 2008 Mar 1;47(3):320-8. doi: 10.1097/qai.0b013e31815e7436.
6
High uptake of exclusive breastfeeding and reduced early post-natal HIV transmission.纯母乳喂养的高普及率与产后早期艾滋病毒传播率的降低。
PLoS One. 2007 Dec 26;2(12):e1363. doi: 10.1371/journal.pone.0001363.
7
The impact of safer breastfeeding practices on postnatal HIV-1 transmission in Zimbabwe.更安全的母乳喂养做法对津巴布韦产后HIV-1传播的影响。
Am J Public Health. 2007 Jul;97(7):1249-54. doi: 10.2105/AJPH.2006.085704. Epub 2007 May 30.
8
Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study.出生后前6个月纯母乳喂养期间HIV-1感染的母婴传播:一项干预队列研究。
Lancet. 2007 Mar 31;369(9567):1107-16. doi: 10.1016/S0140-6736(07)60283-9.
9
Optimal duration of exclusive breastfeeding: what is the evidence to support current recommendations?纯母乳喂养的最佳持续时间:支持当前建议的证据有哪些?
Am J Clin Nutr. 2007 Feb;85(2):635S-638S. doi: 10.1093/ajcn/85.2.635S.
10
CC and CXC chemokines in breastmilk are associated with mother-to-child HIV-1 transmission.母乳中的CC趋化因子和CXC趋化因子与母婴间HIV-1传播有关。
Curr HIV Res. 2005 Oct;3(4):361-9. doi: 10.2174/157016205774370393.