Medical University of Vienna.
Anaesthesia. 2010 Mar;65(3):266-71. doi: 10.1111/j.1365-2044.2010.06247.x. Epub 2010 Jan 29.
Our study group recently evaluated an ED(95) local anaesthetic volume of 0.11 ml.mm(-2) cross-sectional nerve area for the ulnar nerve. This prospective, randomised, double-blind crossover study investigated whether this volume is sufficient for brachial plexus blocks at the axillary level. Ten volunteers received an ultrasonographic guided axillary brachial plexus block either with 0.11 ('low' volume) or 0.4 ('high' volume) ml.mm(-2) cross-sectional nerve area with mepivacaine 1%. The mean (SD) volume was in the low volume group 4.0 (1.0) and 14.8 (3.8) ml in the high volume group. The success rate for the individual nerve blocks was 27 out of 30 in the low volume group (90%) and 30 out of 30 in the high volume group (100%), resulting in 8 out of 10 (80%) vs 10 out of 10 (100%) complete blocks in the low vs the high volume groups, respectively (NS). The mean (SD) sensory onset time was 25.0 (14.8) min in the low volume group and 15.8 (6.8) min in the high volume group (p < 0.01). The mean (SD) duration of sensory block was 125 (38) min in the low volume group and 152 (70) min in the high volume group (NS). This study confirms our previous published ED(95) volume for mepivacaine 1% to block peripheral nerves. The volume of local anaesthetic has some influence on the sensory onset time.
我们的研究小组最近评估了 ED(95)局部麻醉体积为 0.11ml.mm(-2) 用于尺神经的横截面积。这项前瞻性、随机、双盲交叉研究调查了这种体积是否足以用于腋路臂丛阻滞。10 名志愿者接受了超声引导的腋路臂丛阻滞，分别用 0.11（低体积）或 0.4（高体积）ml.mm(-2) 横截面神经区域的甲哌卡因 1%。低体积组的平均（SD）体积为 4.0（1.0），高体积组为 14.8（3.8）ml。低体积组的单个神经阻滞成功率为 30 个中的 27 个（90%），高体积组为 30 个中的 30 个（100%），低体积组的 10 个中的 8 个（80%）与高体积组的 10 个中的 10 个（100%）完全阻滞，分别为（NS）。低体积组的感觉起始时间的平均（SD）为 25.0（14.8）分钟，高体积组为 15.8（6.8）分钟（p < 0.01）。低体积组感觉阻滞的平均（SD）持续时间为 125（38）分钟，高体积组为 152（70）分钟（NS）。这项研究证实了我们之前发表的用 1%甲哌卡因阻滞周围神经的 ED(95)体积。局部麻醉的体积对感觉起始时间有一定的影响。
