Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Melbourne, Australia.
BMC Pulm Med. 2010 Feb 2;10:5. doi: 10.1186/1471-2466-10-5.
Non-cystic fibrosis bronchiectasis is characterised by sputum production, exercise limitation and recurrent infections. Although pulmonary rehabilitation is advocated for this patient group, its effects are unclear. The aims of this study are to determine the short and long term effects of pulmonary rehabilitation on exercise capacity, cough, quality of life and the incidence of acute pulmonary exacerbations.
METHODS/DESIGN: This randomised controlled trial aims to recruit 64 patients with bronchiectasis from three tertiary institutions. Participants will be randomly allocated to the intervention group (supervised, twice weekly exercise training with regular review of airway clearance therapy) or a control group (twice weekly telephone support). Measurements will be taken at baseline, immediately following the intervention and at six and 12 months following the intervention period by a blinded assessor. Exercise capacity will be measured using the incremental shuttle walk test and the six-minute walk test. Quality of life and health status will be measured using the Chronic Respiratory Questionnaire, Leicester Cough Questionnaire, Assessment of Quality of Life Questionnaire and the Hospital Anxiety and Depression Scale. The rate of hospitalisation will be captured as well as the incidence of acute pulmonary exacerbations using a daily symptom diary.
Results from this study will help to determine the efficacy of supervised twice-weekly pulmonary rehabilitation upon exercise capacity and quality of life in patients with bronchiectasis and will contribute to clinical practice guidelines for physiotherapists in the management of this population.
This study protocol is registered with ClinicalTrials.gov (NCT00885521).
非囊性纤维化性支气管扩张症的特征是咳痰、运动受限和反复感染。虽然提倡对该患者群体进行肺康复治疗，但其疗效尚不清楚。本研究的目的是确定肺康复对运动能力、咳嗽、生活质量和急性肺部恶化发作发生率的短期和长期影响。
方法/设计：这是一项随机对照试验，旨在从三所三级医院招募 64 名支气管扩张症患者。参与者将被随机分配到干预组（监督，每周两次运动训练，定期检查气道清除治疗）或对照组（每周两次电话支持）。由盲法评估员在基线、干预后立即以及干预期后 6 个月和 12 个月进行测量。运动能力将使用递增穿梭步行试验和 6 分钟步行试验进行测量。使用慢性呼吸系统问卷、莱斯特咳嗽问卷、生活质量评估问卷和医院焦虑抑郁量表来衡量生活质量和健康状况。将通过每日症状日记记录住院率和急性肺部恶化发作的发生率。
这项研究的结果将有助于确定监督性每周两次肺康复对支气管扩张症患者运动能力和生活质量的疗效，并为物理治疗师管理该人群的临床实践指南做出贡献。
本研究方案在 ClinicalTrials.gov 注册（NCT00885521）。
