Araki S, Aono H, Murata K
Arch Environ Health. 1986 May-Jun;41(3):171-7. doi: 10.1080/00039896.1986.9935773.
The effects of urinary volume on adjusted and nonadjusted urinary excretion of 11 heavy metals and organic substances were examined in relation to plasma and erythrocyte concentrations in 19 metal workers under conditions of water restriction and loading. Blood lead concentrations in these workers ranged from 25 to 59 micrograms/dl. The results indicated that: urinary volume significantly affects not only nonadjusted urinary concentration for all substances, but also affects timed excretion and concentrations adjusted to urinary specific gravity and to urinary creatinine for most substances; the concentration adjusted to urinary volume is, on the other hand, independent of urinary volume; and urinary excretion of lead and mercury is related more closely to erythrocyte concentration than to plasma concentration. This last finding reflects complex renal excretory mechanisms for these heavy metals.
在限水和饮水负荷条件下，对19名金属工人的尿量对11种重金属和有机物质的校正和未校正尿排泄的影响进行了研究，并与血浆和红细胞浓度相关联。这些工人的血铅浓度范围为25至59微克/分升。结果表明：尿量不仅显著影响所有物质的未校正尿浓度，而且影响大多数物质的定时排泄以及根据尿比重和尿肌酐校正后的浓度；另一方面，根据尿量校正后的浓度与尿量无关；铅和汞的尿排泄与红细胞浓度的关系比与血浆浓度的关系更密切。这一最新发现反映了这些重金属复杂的肾脏排泄机制。
