高迁移率族蛋白B1：在碱基切除修复及相关功能中的作用
HMGB1: roles in base excision repair and related function.
作者信息
Liu Yuan, Prasad Rajendra, Wilson Samuel H
机构信息
Laboratory of Structural Biology, The National Institute of Environmental Health Sciences, National Institutes of Health, 111 T. W. Alexander Drive Research Triangle Park, NC 27709, USA.
出版信息
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):119-30. doi: 10.1016/j.bbagrm.2009.11.008.
Abstract
High mobility group box 1 (HMGB1) is a nonhistone architectural protein that is involved in many biological processes including chromatin remodeling, transcription, cell signaling of inflammation, DNA damage repair and others. Recent studies have identified the cross-link of HMGB1 with a DNA base excision repair intermediate indicating that this protein is involved in base excision repair (BER) pathway. Further characterization of the roles of HMGB1 in BER demonstrates that the protein acts as a cofactor to regulate BER sub-pathways by inhibiting single-nucleotide BER and stimulating long-patch BER through modulating the activities of base excision repair enzymes. Directing of base lesion repair to the long-patch sub-pathway can result in trinucleotide repeat instability suggesting an important role of HMGB1 in modulating genome stability.
摘要
高迁移率族蛋白B1（HMGB1）是一种非组蛋白结构蛋白，参与许多生物学过程，包括染色质重塑、转录、炎症细胞信号传导、DNA损伤修复等。最近的研究发现HMGB1与DNA碱基切除修复中间体交联，表明该蛋白参与碱基切除修复（BER）途径。对HMGB1在BER中作用的进一步表征表明，该蛋白作为一种辅助因子，通过抑制单核苷酸BER并通过调节碱基切除修复酶的活性刺激长片段BER来调节BER子途径。将碱基损伤修复导向长片段子途径可导致三核苷酸重复不稳定，提示HMGB1在调节基因组稳定性中起重要作用。
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