Faculty of Translational Medicine, Guy's, St. Thomas' and King's College London Comprehensive Biomedical Research Centre, Great Maze Pond, London SE1 9RT, UK.
Nat Rev Gastroenterol Hepatol. 2010 Mar;7(3):146-56. doi: 10.1038/nrgastro.2010.5. Epub 2010 Feb 2.
Eosinophils are potent innate immune cells that home to the gastrointestinal tract where they participate in host immunity to luminal pathogens, and help to maintain intestinal epithelial homeostasis. However, these cells are now recognized to have key functions in the pathogenesis of numerous other disorders of the gastrointestinal tract, including primary eosinophilic gastrointestinal disease, common functional conditions, such as dyspepsia, and also in gastrointestinal disorders in patients with allergic disease. We are just beginning to understand the potential pathological role of eosinophils in gastrointestinal disease, and it is increasingly likely that gastroenterologists and histopathologists will need to account for the presence of gastrointestinal eosinophils and relate their presence to gastrointestinal symptoms. This Review discusses the role of gastrointestinal eosinophils in health and disease, including their associations with functional and allergic disorders.
嗜酸性粒细胞是强有力的先天免疫细胞，它们归巢到胃肠道，在那里参与宿主对腔病原体的免疫，并有助于维持肠道上皮细胞的稳态。然而，这些细胞现在被认为在许多其他胃肠道疾病的发病机制中具有关键作用，包括原发性嗜酸性粒细胞性胃肠道疾病、常见的功能性疾病，如消化不良，以及过敏性疾病患者的胃肠道疾病。我们才刚刚开始了解嗜酸性粒细胞在胃肠道疾病中的潜在病理作用，越来越有可能的是，胃肠病学家和组织病理学家将需要考虑到胃肠道嗜酸性粒细胞的存在，并将其与胃肠道症状联系起来。这篇综述讨论了胃肠道嗜酸性粒细胞在健康和疾病中的作用，包括它们与功能性和过敏性疾病的关联。
