Department of Medicine, University College Medical School, Rayne Institute, Centre for Respiratory Research, London, United Kingdom.
PLoS One. 2010 Jan 26;5(1):e8902. doi: 10.1371/journal.pone.0008902.
Streptococcus pneumoniae is a common cause of infection in both HIV positive patients and those with complement deficiencies. We hypothesised that HIV positive individuals might exhibit reduced opsonisation of pneumococcus with complement due to reduced levels of S. pneumoniae specific IgG. We discovered no difference in C3 deposition on S. pneumoniae between HIV positive or negative individuals, and furthermore C3 deposition remained unchanged as HIV progressed towards AIDS. We found no correlation between C3 deposition on S. pneumoniae and CD4 cell count in HIV infected individuals. Hence we have demonstrated no failure of complement immunity in HIV positive patients.
肺炎链球菌是 HIV 阳性患者和补体缺陷患者感染的常见原因。我们假设，由于 HIV 阳性个体的肺炎链球菌特异性 IgG 水平降低，他们对肺炎链球菌的调理作用可能会减弱。我们发现 HIV 阳性或阴性个体的肺炎链球菌上 C3 沉积没有差异，而且随着 HIV 向艾滋病发展，C3 沉积保持不变。我们还发现，HIV 感染者的肺炎链球菌上 C3 沉积与 CD4 细胞计数之间没有相关性。因此，我们证明了 HIV 阳性患者的补体免疫功能并未失效。
