Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui, China.
Eur J Clin Pharmacol. 2010 May;66(5):511-8. doi: 10.1007/s00228-009-0781-x. Epub 2010 Feb 2.
To describe the pattern of drug use among Chinese women during the first trimester and to examine the impact of maternal diseases on the choice of drugs.
This drug utilisation study of pregnant women was performed using data from the ABCD cohort study. A total of 4,290 women were enrolled in the analysis. Information was collected by self-completion questionnaire combined with the "Maternal health handbook".
Of the 4,290 women interviewed, 75.9% of women took at least one drug during the first trimester. Users took a mean number of 1.43 drugs. The most frequently used drugs were folic acid (65.2%), vitamins (14.6%), calcium (12.0%), minerals (11.1%), Chinese traditional patent medicine (CTPM; 10.1%) and anti-infectives (6.5%). Among the women having used CTPM, influenza/cold and threatened abortion were the most commonly reported indications. Logistic regression analysis of drug use (excluding nutritional and haematological drugs) shows that CTPM and Western medicine are both associated with the use of drugs for occasional diseases and against threatened abortion. Maternal chronic diseases were not associated with the use of CTPM.
This analysis of pregnant women showed that drugs were prescribed to most women, even when nutritional and haematological drugs were excluded. Our data reflect, except for drugs used for chronic diseases, a general reluctance among Chinese women to use Western medicine and resorting to CTPM during pregnancy.
描述中国孕妇在孕早期的用药模式，并探讨母体疾病对药物选择的影响。
本项药物利用研究采用 ABCD 队列研究的数据。共纳入 4290 名女性进行分析。通过自填式问卷结合《孕产妇保健手册》收集信息。
在所调查的 4290 名女性中，75.9%的孕妇在孕早期至少使用了一种药物。使用者平均使用了 1.43 种药物。最常使用的药物是叶酸（65.2%）、维生素（14.6%）、钙（12.0%）、矿物质（11.1%）、中药（10.1%）和抗感染药（6.5%）。在使用中药的女性中，感冒/流感和先兆流产是最常见的报告适应证。对药物使用（不包括营养和血液学药物）进行逻辑回归分析表明，中药和西药均与偶发性疾病和先兆流产的药物使用有关。母体慢性疾病与中药的使用无关。
本项对孕妇的分析显示，即使不包括营养和血液学药物，大多数孕妇也会使用药物。除了用于治疗慢性疾病的药物外，我们的数据反映了中国女性普遍不愿意在怀孕期间使用西药，而是倾向于使用中药。
