炎症性肠病和急性自限性结肠炎中隐窝脓肿相关的微生物组。
Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.
机构信息
Gastroenterology and Nutrition Department, Saint Antoine Hospital, Pierre et Marie Curie-Paris6 University, AP-HP, 184 rue du Faubourg Saint-Antoine, 75571, Paris, France.
出版信息
World J Gastroenterol. 2010 Feb 7;16(5):583-7. doi: 10.3748/wjg.v16.i5.583.
AIM
To evaluate whether crypt abscesses from inflammatory bowel disease (IBD) patients contain bacteria and to establish their nature.
METHODS
We studied 17 ulcerative colitis patients, 11 Crohn's disease patients, 7 patients with acute self-limited colitis (ASLC) and normal colonic biopsies from 5 subjects who underwent colonoscopy for colon cancer screening. A fluorescent in situ hybridization technique was applied to colonic biopsies to assess the microbiota composition of the crypts and crypt abscesses.
RESULTS
Crypts colonized by bacteria were observed in 42.9% and 3.6% of ASLC and IBD patients, respectively (P = 0.019). Crypt abscesses colonized by bacteria were observed in 28.6% and 0.0% of ASLC and IBD patients, respectively (P = 0.035).
CONCLUSION
These results do not support the hypothesis that crypt abscesses in IBD are the result of localized dysbiosis arising from persistence of living bacteria colonizing the crypts.
目的
评估炎症性肠病（IBD）患者的隐窝脓肿中是否存在细菌，并确定其性质。
方法
我们研究了 17 例溃疡性结肠炎患者、11 例克罗恩病患者、7 例急性自限性结肠炎（ASLC）患者和 5 例因结肠癌筛查而行结肠镜检查的正常结肠活检患者的隐窝脓肿。应用荧光原位杂交技术评估结肠隐窝和隐窝脓肿的微生物群落组成。
结果
分别有 42.9%和 3.6%的 ASLC 和 IBD 患者的隐窝被细菌定植（P=0.019）。分别有 28.6%和 0.0%的 ASLC 和 IBD 患者的隐窝脓肿被细菌定植（P=0.035）。
结论
这些结果不支持 IBD 患者的隐窝脓肿是由定植于隐窝的活菌引起的局部菌群失调的假说。
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