肉苁蓉黄酮提取物对大鼠游泳耐力的影响。
Effects of a flavonoid extract from Cynomorium songaricum on the swimming endurance of rats.
机构信息
Gansu Institute of Political Science and Law, Lanzhou, China.
出版信息
Am J Chin Med. 2010;38(1):65-73. doi: 10.1142/S0192415X10007774.
The present study investigated the effects of a flavonoid extract from Cynomorium songaricum on the swimming endurance of rats by measuring changes of free radical scavenging enzymes, such as CuZn-SOD (copper, zinc-superoxide dismutase) and GSH-px (glutathione peroxidase), and body weights. Significant and dose-dependent antioxidant and anti-fatigue effects of flavonoids (rutin, catechin and isoquercitrin) on swimming rats were observed during 10 days of swimming exercise. After treatment with the flavonoid extract at doses of 0.5, 1.0, and 2.0 g/kg body weight, the CuZn-SOD and GSH-px activities in swimming rats were increased by 1.4%, 3.3%, 4.1% and 112.2%, 208.7%, 261.7%, respectively, while the levels of MDA (malondialdehyde) were decreased by 64.7%, 79.4%, and 86.4% respectively. Furthermore, the average body weight and the total swimming time were increased by 3.1%, 8.8%, 10.6%, and 7.7%, 34.5%, 61.5%, respectively. Our experimental results suggest that flavonoid supplementation could not only reduce free radical formation and scavenge free radicals, but also enhance endurance exercise performance by reducing muscle fatigue.
本研究通过测量自由基清除酶（如 CuZn-SOD 和 GSH-px）和体重的变化，研究了从肉苁蓉中提取的类黄酮对大鼠游泳耐力的影响。在 10 天的游泳运动中，观察到类黄酮（芦丁、儿茶素和异槲皮苷）对游泳大鼠具有显著的、剂量依赖性的抗氧化和抗疲劳作用。用 0.5、1.0 和 2.0 g/kg 体重的类黄酮提取物处理后，游泳大鼠的 CuZn-SOD 和 GSH-px 活性分别增加了 1.4%、3.3%、4.1%和 112.2%、208.7%、261.7%，而 MDA（丙二醛）水平分别降低了 64.7%、79.4%和 86.4%。此外，平均体重和总游泳时间分别增加了 3.1%、8.8%、10.6%和 7.7%、34.5%、61.5%。我们的实验结果表明，类黄酮补充剂不仅可以减少自由基的形成和清除自由基，还可以通过减少肌肉疲劳来提高耐力运动表现。
Zotero 插件