Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA.
J Neurosci. 2010 Feb 3;30(5):1760-5. doi: 10.1523/JNEUROSCI.5636-09.2010.
Memory and its underlying neural plasticity play important roles in sensory discrimination and cortical pattern recognition in olfaction. Given the reported function of slow-wave sleep states in neocortical and hippocampal memory consolidation, we hypothesized that activity during slow-wave states within the piriform cortex may be shaped by recent olfactory experience. Rats were anesthetized with urethane and allowed to spontaneously shift between slow-wave and fast-wave states as recorded in local field potentials within the anterior piriform cortex. Single-unit activity of piriform cortical layer II/III neurons was recorded simultaneously. The results suggest that piriform cortical activity during slow-wave states is shaped by recent (several minutes) odor experience. The temporal structure of single-unit activity during slow waves was modified if the animal had been stimulated with an odor within the receptive field of that cell. If no odor had been delivered, the activity of the cell during slow-wave activity was stable across the two periods. The results demonstrate that piriform cortical activity during slow-wave state is shaped by recent odor experience, which could contribute to odor memory consolidation.
记忆及其基础的神经可塑性在嗅觉的感觉辨别和皮质模式识别中起着重要作用。鉴于慢波睡眠状态在新皮质和海马体记忆巩固中的报告功能，我们假设在梨状皮层内的慢波状态期间的活动可能会受到最近嗅觉体验的影响。用尿烷麻醉大鼠，并允许其在前梨状皮层的局部场电位中自发地在慢波和快波状态之间转换。同时记录梨状皮层 II/III 层神经元的单细胞活动。结果表明，慢波状态下的梨状皮层活动受到最近（几分钟）气味体验的影响。如果动物在细胞的感受野内受到气味刺激，则在慢波期间的单细胞活动的时间结构会发生改变。如果没有气味被传递，则细胞在慢波活动期间的活动在两个时间段内是稳定的。结果表明，慢波状态下的梨状皮层活动是由最近的气味体验塑造的，这可能有助于气味记忆的巩固。
