基于 fMRI 的大鼠嗅觉系统状态依赖功能连接研究。
State-dependent functional connectivity of rat olfactory system assessed by fMRI.
机构信息
Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, USA.
出版信息
Neurosci Lett. 2011 Jun 22;497(2):69-73. doi: 10.1016/j.neulet.2011.04.031. Epub 2011 Apr 22.
Abstract
Functional connectivity between the piriform cortex and limbic and neocortical areas was assessed using functional magnetic resonance imaging (fMRI) of urethane anesthetized rats that spontaneously cycled between slow-wave and fast-wave states. Slow-wave and fast-wave states were determined indirectly through monitoring of respiration rate, which was confirmed to co-vary with state as determined by electrophysiological recordings. Previous electrophysiological data have suggested that the piriform cortex shifts between responsiveness to afferent odor input during fast-wave states and enhanced functional connectivity with limbic areas during slow-wave state. The present results demonstrate that fMRI-based resting state functional connectivity between the piriform cortex and both limbic and neocortical areas is enhanced during slow-wave state compared to fast-wave state using respiration as an indirect measure of state in urethane anesthetized rats. This state-dependent shift in functional connectivity may be important for sleep-dependent odor memory consolidation.
摘要
使用功能磁共振成像 (fMRI) 评估了在自发地在慢波和快波状态之间循环的氨基甲酸乙酯麻醉大鼠的梨状皮层与边缘和新皮层区域之间的功能连接。慢波和快波状态通过监测呼吸频率间接确定，通过电生理记录证实与状态共变。先前的电生理数据表明，在快波状态下，梨状皮层对传入气味输入的反应性发生变化，而在慢波状态下，与边缘区域的功能连接增强。本研究结果表明，使用呼吸作为氨基甲酸乙酯麻醉大鼠状态的间接测量，与快波状态相比，慢波状态下基于 fMRI 的梨状皮层与边缘和新皮层区域之间的静息状态功能连接增强。这种功能连接的状态依赖性变化可能对睡眠依赖性气味记忆巩固很重要。
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