Gastroenteritis Section, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Vic., Australia.
Intervirology. 2010;53(3):167-72. doi: 10.1159/000279764. Epub 2010 Feb 3.
The molecular and epidemiological features of community-based norovirus-associated sporadic gastroenteritis incidents (NASGIs) are poorly understood. This study examined these features and compared the findings with studies of community-based and institutional norovirus-associated gastroenteritis outbreaks (NAGOs).
Fecal specimens from NASGIs and NAGOs that occurred in Victoria, Australia (2002-2007) were tested for norovirus by reverse transcription-polymerase chain reaction methodology. Norovirus genotype was determined by nucleotide sequence analysis.
106 community-based NASGIs, 116 community-based NAGOs and 902 institutional NAGOs were identified. The mean age and gender ratio of individuals associated with community-based NASGIs and community-based NAGOs were similar but differed from that found for institutional NAGOs. Although GII.4 was the predominant genotype associated with all three incident types, the mix of genotypes was similar for community-based NASGIs and community-based NAGOs but that for institutional NAGOs was different. All three incident types had a similar seasonal periodicity due to the pronounced seasonal periodicity of GII.4 incidents.
The molecular and epidemiological features of noroviruses associated with community-based NASGIs and community-based NAGOs are similar but are different from those found for institutional NAGOs.
社区为基础的诺如病毒相关散发型胃肠炎事件（NASGIs）的分子和流行病学特征尚未得到充分了解。本研究检测了这些特征，并将结果与社区为基础和机构为基础的诺如病毒相关胃肠炎暴发（NAGOs）的研究进行了比较。
对澳大利亚维多利亚州（2002-2007 年）发生的 NASGIs 和 NAGOs 的粪便标本进行了逆转录-聚合酶链反应方法检测诺如病毒。通过核苷酸序列分析确定诺如病毒基因型。
确定了 106 例社区为基础的 NASGIs、116 例社区为基础的 NAGOs 和 902 例机构为基础的 NAGOs。与社区为基础的 NASGIs 和社区为基础的 NAGOs 相关的个体的平均年龄和性别比例相似，但与机构为基础的 NAGOs 不同。虽然 GII.4 是与所有三种事件类型都相关的主要基因型，但社区为基础的 NASGIs 和社区为基础的 NAGOs 的基因型组合相似，而机构为基础的 NAGOs 的基因型组合则不同。由于 GII.4 事件的明显季节性周期性，所有三种事件类型都具有相似的季节性周期性。
与社区为基础的 NASGIs 和社区为基础的 NAGOs 相关的诺如病毒的分子和流行病学特征与机构为基础的 NAGOs 不同，但与机构为基础的 NAGOs 相似。
