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[单次及多次妊娠对仓鼠中SV40病毒诱导的原发性肿瘤发生率的影响]

[Influence of single and repeated pregnancies on the incidence of primary tumors induced by SV40 virus in hamsters].

作者信息

Vendrov E L

出版信息

Biull Eksp Biol Med. 1977 Nov;84(11):595-7.

PMID:201317
Abstract

The influence of the single and repeated pregnancies on the SV40-induced carcinogenesis in Syrian hamsters was studied. It was shown that the frequency of the primary tumours in females which become pregnant 1-5 times during the latent period of SV40 carcinogenesis was significantly lower in comparison with virgin females observed in the same experiment. However, these differences apparently had no connection with the immunization of multiparous females with embryonic antigens, as the frequency and the time of appearance of primary tumours in males were the same as in multiparous females.

摘要

研究了单次和重复怀孕对叙利亚仓鼠中SV40诱导致癌作用的影响。结果表明,在SV40致癌潜伏期怀孕1 - 5次的雌性动物中,原发性肿瘤的发生率与同一实验中观察到的未孕雌性相比显著降低。然而,这些差异显然与经胚胎抗原免疫的多胎雌性动物无关,因为雄性动物中原发性肿瘤的发生率和出现时间与多胎雌性相同。

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