Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Section 2, Nei-hu 114, Taipei, Taiwan.
Br J Dermatol. 2010 May;162(5):1110-6. doi: 10.1111/j.1365-2133.2010.09679.x. Epub 2010 Feb 3.
Children with atopic dermatitis (AD) are more frequently colonized by Staphylococcus aureus than healthy children.
To assess whether any relationship exists between nasal meticillin-resistant S. aureus (MRSA) colonization and subsequent skin and soft-tissue infections (SSTI).
From 2005 through 2006, comparative molecular analyses of 23 MRSA-colonizing isolates from 133 children with AD, 44 MRSA-colonizing isolates from 490 healthy controls, and 12 MRSA-infecting isolates from 20 children with AD and concurrent SSTI were conducted.
Nasal MRSA colonization in children with AD was significantly higher compared with normal individuals (17.3% vs. 9.0%; P = 0.01). The molecular characteristics differed significantly between the MRSA isolates from children with AD and the MRSA-colonizing isolates from healthy controls. The clone characterized as sequence type (ST)59 (338)/pulsotype B/staphylococcal cassette chromosome mec (SCCmec) V(T)/Panton-Valentine leucocidin (PVL)-positive/staphylococcal enterotoxin B (SEB)-positive accounted for half of the MRSA isolates from children with AD, and another clone, characterized as ST59/pulsotype A/SCCmec IV/PVL-negative/SEB-positive accounted for 61% of the MRSA-colonizing isolates from healthy controls.
We found MRSA colonizing the anterior nares of a large number of Taiwanese children, especially among those with AD. Analysis of our data provides evidence that links MRSA-colonizing isolates to MRSA-infecting isolates from concurrent SSTI in children with AD.
患有特应性皮炎（AD）的儿童比健康儿童更容易定植金黄色葡萄球菌。
评估鼻腔耐甲氧西林金黄色葡萄球菌（MRSA）定植与随后发生的皮肤和软组织感染（SSTI）之间是否存在任何关系。
在 2005 年至 2006 年期间，对 133 例 AD 患儿中 23 例 MRSA 定植分离株、490 例健康对照者中 44 例 MRSA 定植分离株和 20 例并发 SSTI 的 AD 患儿中 12 例 MRSA 感染分离株进行了比较分子分析。
AD 患儿鼻腔 MRSA 定植率明显高于正常个体（17.3%比 9.0%；P=0.01）。AD 患儿 MRSA 分离株与健康对照者 MRSA 定植分离株的分子特征有显著差异。该克隆特征为序列类型（ST）59（338）/脉冲型 B/葡萄球菌盒染色体 mec（SCCmec）V（T）/金葡菌杀白细胞素（PVL）阳性/葡萄球菌肠毒素 B（SEB）阳性，占 AD 患儿 MRSA 分离株的一半，另一个克隆特征为 ST59/脉冲型 A/SCCmec IV/PVL 阴性/SEB 阳性，占健康对照者 MRSA 定植分离株的 61%。
我们发现大量台湾儿童的前鼻腔定植了 MRSA，尤其是 AD 患儿。我们的数据分析提供了证据，将 MRSA 定植分离株与 AD 患儿并发 SSTI 的 MRSA 感染分离株联系起来。
