Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Epilepsia. 2010 Aug;51(8):1619-23. doi: 10.1111/j.1528-1167.2009.02515.x.
The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically.We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2–3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.
生酮饮食对行为和认知的影响尚不清楚。我们在大鼠的行为和电生理方面研究了这个问题。我们用标准饮食（SD）、生酮饮食（KD）或热量限制饮食（CR）喂养出生后 21 天的大鼠 2-3 周。CR 控制了 KD 喂养的大鼠体重增长较慢的问题。我们用运动活动和条件性恐惧测试评估行为表现。为了评估饮食对突触功能的可能平行影响，我们在体内检查了中内嗅皮层的成对脉冲调制（PPM）和长时程增强（LTP）。KD 喂养的大鼠在行为测试和电生理测定中的表现与 SD 喂养的大鼠相似。这些数据表明 KD 不会改变行为表现或突触可塑性。
