Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Brain Behav. 2019 Apr;9(4):e01246. doi: 10.1002/brb3.1246. Epub 2019 Mar 7.
Beyond its application as an epilepsy therapy, the ketogenic diet (KD) has been considered a potential treatment for a variety of other neurological and metabolic disorders. However, whether KD promotes functional restoration by reducing the pathological processes underlying individual diseases or through some independent mechanisms is not clear.
In this study, we evaluated the effect of KD on a series of behaviors and synaptic functions of young adult naive mice. Wild-type C57BL/6J mice at age of 2-3 months were fed with control diet or KD for three months. Body weight and caloric intake were monitored throughout the experiments. We assessed behavioral performance with seizure induction, motor coordination and activity, anxiety level, spatial learning and memory, sociability, and depression. Synaptic transmission and long-term potentiation were also recorded.
KD-fed mice performed equivalent to control-diet-fed mice in the behavioral tests and electrophysiological assays except exhibiting slower weight gain and increased seizure threshold.
Our results contribute to the better understanding of effects of the KD on physiological behaviors and synaptic functions.
ketogenic 饮食（KD）除了被应用于癫痫治疗外，还被认为是治疗多种神经和代谢疾病的潜在方法。然而，KD 是否通过减轻各种疾病的病理过程或通过某些独立的机制来促进功能恢复尚不清楚。
在这项研究中，我们评估了 KD 对年轻成年未患病小鼠一系列行为和突触功能的影响。在 2-3 月龄时，将野生型 C57BL/6J 小鼠用对照饮食或 KD 喂养 3 个月。在整个实验过程中监测体重和热量摄入。我们通过诱发癫痫、运动协调和活动、焦虑水平、空间学习和记忆、社交能力和抑郁来评估行为表现。还记录了突触传递和长时程增强。
KD 喂养的小鼠在行为测试和电生理测定中的表现与对照饮食喂养的小鼠相当，除了体重增加较慢和癫痫发作阈值增加。
我们的结果有助于更好地理解 KD 对生理行为和突触功能的影响。
