视网膜杆状和锥状光感受器的吞噬作用。
Phagocytosis of retinal rod and cone photoreceptors.
机构信息
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
出版信息
Physiology (Bethesda). 2010 Feb;25(1):8-15. doi: 10.1152/physiol.00038.2009.
Abstract
Photoreceptor cells maintain a roughly constant length by continuously generating new outer segments from their base while simultaneously releasing mature outer segments engulfed by the retinal pigment epithelium (RPE). Thus postmitotic RPE cells phagocytose an immense amount of material over a lifetime, disposing of photoreceptor cell waste while retaining useful content. This review focuses on current knowledge of outer segment phagocytosis, discussing the steps involved along with their critical participants as well as how various perturbations in outer segment (OS) disposal can lead to retinopathies.
摘要
感光细胞通过从其基部不断产生新的外节来维持大致恒定的长度，同时释放被视网膜色素上皮 (RPE) 吞噬的成熟外节。因此，有丝分裂后的 RPE 细胞在其一生中吞噬了大量的物质，在清除光感受器细胞废物的同时保留有用的内容。本综述重点介绍了目前对外节吞噬的认识，讨论了涉及的步骤及其关键参与者，以及外节 (OS) 处理的各种干扰如何导致视网膜病变。
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2
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3
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