Carleton Maya, Oesch Nicholas W
Department of Psychology, University of California San Diego, La Jolla, CA, United States.
Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States.
Front Cell Neurosci. 2024 Nov 21;18:1502473. doi: 10.3389/fncel.2024.1502473. eCollection 2024.
Retinitis pigmentosa (RP) and Age-Related Macular Degeneration (AMD) are similar in that both result in photoreceptor degeneration leading to permanent progressive vision loss. This affords the possibility of implementing vision restoration techniques, where light signaling is restored to spared retinal circuitry to recreate vision. There are far more AMD patients (Wong et al., 2014), yet more resources have been put towards researching and developing vision restoration strategies for RP despite it rarity, because of the tractability of RP disease models. The hope is that these therapies will extend to the AMD population, however, many questions remain about how the implementation of prosthetic or optogenetic vision restoration technologies will translate between RP and AMD patients. In this review, we discuss the difference and similarities of RP and AMD with a focus on aspects expected to impact vision restoration strategies, and we identify key gaps in knowledge needed to further improve vision restoration technologies for a broad patient population.
视网膜色素变性（RP）和年龄相关性黄斑变性（AMD）的相似之处在于，两者都会导致光感受器退化，进而导致永久性渐进性视力丧失。这为实施视觉恢复技术提供了可能性，即通过恢复光信号到未受损的视网膜回路来重建视觉。AMD患者的数量要多得多（Wong等人，2014年），然而，尽管RP较为罕见，但由于RP疾病模型具有易处理性，更多的资源已投入到针对RP的视觉恢复策略的研究和开发中。人们希望这些疗法能够推广到AMD患者群体，然而，关于假体或光遗传学视觉恢复技术在RP和AMD患者之间的应用如何转化，仍有许多问题。在这篇综述中，我们讨论了RP和AMD的异同，重点关注预期会影响视觉恢复策略的方面，并确定了进一步改进针对广大患者群体的视觉恢复技术所需的关键知识空白。
