电压门控质子通道在吞噬细胞中找到了管理呼吸爆发的理想工作。
Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes.
机构信息
Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, USA.
出版信息
Physiology (Bethesda). 2010 Feb;25(1):27-40. doi: 10.1152/physiol.00039.2009.
Abstract
The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1-S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.
摘要
电压门控质子通道与其他电压门控离子通道的电压感应结构域（S1-S4）惊人地相似，但它是一个具有两条传导途径的二聚体。质子通道似乎是为了从细胞中高效排出质子而设计的。在吞噬细胞中，它有助于 NADPH 氧化酶产生活性氧物质。
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