质子通道与NADPH氧化酶之间密切而神秘的关系。
The intimate and mysterious relationship between proton channels and NADPH oxidase.
作者信息
Musset Boris, Cherny Vladimir V, Morgan Deri, DeCoursey Thomas E
机构信息
Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612, USA.
出版信息
FEBS Lett. 2009 Jan 5;583(1):7-12. doi: 10.1016/j.febslet.2008.12.005. Epub 2008 Dec 10.
Abstract
Voltage gated proton channels and NADPH oxidase function cooperatively in phagocytes during the respiratory burst, when reactive oxygen species are produced to kill microbial invaders. Although these molecules are distinct entities, with no proven physical interaction, their presence and activity in many cells appears to be coordinated. We describe these interactions and discuss several types of mechanisms that might explain them.
摘要
在呼吸爆发期间，电压门控质子通道与NADPH氧化酶在吞噬细胞中协同发挥作用，此时会产生活性氧以杀死微生物入侵者。尽管这些分子是不同的实体，尚未证实存在物理相互作用，但它们在许多细胞中的存在和活性似乎是协调的。我们描述了这些相互作用，并讨论了几种可能解释它们的机制。
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