Division of Respiratory Diseases, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy.
Respiration. 2010;80(2):112-9. doi: 10.1159/000281880. Epub 2010 Feb 4.
Chronic obstructive pulmonary disease (COPD) is associated with many comorbidities, but the percentage of COPD patients who develop comorbidities has not been clearly defined.
We aimed to examine the relationship between COPD and comorbidities using information obtained from the Health Search Database (HSD) owned by the Italian College of General Practitioners (SIMG), which stores information on about 1.5% of the total Italian population served by general practitioners.
We conducted a population-based retrospective study using information obtained from the HSD. The software system used codes all the diagnostic records using the 9th Revision of the International Classification of Diseases.
Compared to the non-COPD people, COPD patients were at increased risk for cardiovascular events [ischemic heart disease (6.9% in the general population vs. 13.6% in COPD patients), cardiac arrhythmia (6.6% in the general population vs. 15.9% in COPD patients), heart failure (2.0% in the general population vs. 7.9% in COPD patients), and other forms of heart disease (10.7% in the general population vs. 23.1% in COPD patients); with a higher impact of COPD in the elderly]; non-psychotic mental disorders, including depressive disorders (29.1% in the general population vs. 41.6% in COPD patients; with a higher impact of COPD on women aged <75 years); diabetes mellitus (10.5% in the general population vs. 18.7% in COPD patients); osteoporosis (10.8% in the general population vs. 14.8% in COPD patients), with a higher impact of COPD on women aged <75 years, and malignant pulmonary neoplasms (0.4% in the general population vs. 1.9% in COPD patients).
Our results indicate that COPD is a risk factor for these comorbid conditions.
慢性阻塞性肺疾病（COPD）与许多合并症相关，但患有合并症的 COPD 患者的比例尚未明确界定。
我们旨在使用意大利全科医生学院（SIMG）拥有的健康搜索数据库（HSD）中获取的信息来检查 COPD 与合并症之间的关系，该数据库存储了约 1.5%由全科医生服务的意大利总人口的信息。
我们使用 HSD 中获取的信息进行了一项基于人群的回顾性研究。该软件系统使用 9 版国际疾病分类对所有诊断记录进行编码。
与非 COPD 人群相比，COPD 患者发生心血管事件的风险增加[缺血性心脏病（普通人群中的 6.9%与 COPD 患者中的 13.6%相比），心律失常（普通人群中的 6.6%与 COPD 患者中的 15.9%相比），心力衰竭（普通人群中的 2.0%与 COPD 患者中的 7.9%相比）和其他形式的心脏病（普通人群中的 10.7%与 COPD 患者中的 23.1%相比）；对老年人的影响更大]；非精神病性精神障碍，包括抑郁障碍（普通人群中的 29.1%与 COPD 患者中的 41.6%相比；对<75 岁的女性影响更大）；糖尿病（普通人群中的 10.5%与 COPD 患者中的 18.7%相比）；骨质疏松症（普通人群中的 10.8%与 COPD 患者中的 14.8%相比），对<75 岁的女性影响更大，以及恶性肺肿瘤（普通人群中的 0.4%与 COPD 患者中的 1.9%相比）。
我们的结果表明 COPD 是这些合并症的危险因素。
