Valori R M, Hallisey M T, Dunn J
Department of Medicine, West Midlands Cancer Research Campaign, Queen Elizabeth Hospital, Edgbaston, Birmingham.
Gut. 1991 Mar;32(3):236-9. doi: 10.1136/gut.32.3.236.
The hypothesis that oesophageal peristalsis can be modified voluntarily was explored. Six healthy male volunteers and eight female patients with angina like chest pain underwent oesophageal manometry. Each was asked to take a series of swallows, and to vary their size, in random order, by taking either a big gulp or a little swallow. None of the subjects experienced difficulty in doing so. In both groups the amplitude of oesophageal contractions were significantly greater after big gulps than little swallows (p less than 0.01) and this was true for wet (82.0 v 68.9 mmHg) and dry swallows (52.3 v 43.3 mmHg). For the patients' wet swallows the mean values were 73.0 and 56.0 mmHg. Thus, the amplitude of oesophageal peristalsis can be controlled voluntarily. This effect may account for some of the within subject variation in the amplitude of oesophageal contractions. During oesophageal manometry subjects should be encouraged to standardise the size of their swallows whenever possible. Patients with symptoms related to abnormal oesophageal peristalsis such as dysphagia, heartburn, and chest pain may benefit from biofeedback training.
对食管蠕动能否被自主改变这一假设进行了探究。六名健康男性志愿者和八名患有心绞痛样胸痛的女性患者接受了食管测压。要求每个人按随机顺序进行一系列吞咽动作，并通过大口吞咽或小口吞咽来改变吞咽的大小。所有受试者均无困难。在两组中，大口吞咽后食管收缩幅度均显著大于小口吞咽（p小于0.01），无论是湿吞咽（82.0对68.9 mmHg）还是干吞咽（52.3对43.3 mmHg）均如此。对于患者的湿吞咽，平均值分别为73.0和56.0 mmHg。因此，食管蠕动幅度可以被自主控制。这种效应可能解释了食管收缩幅度在个体内部的一些变化。在食管测压期间，应尽可能鼓励受试者使吞咽大小标准化。患有与食管蠕动异常相关症状（如吞咽困难、烧心和胸痛）的患者可能会从生物反馈训练中受益。
