Villari D, Raimondo G, Brancatelli S, Longo G, Rodinò G, Smedile V
Dipartimento di Patologia Umana, Policlinico Universitario di Messina, Italy.
Histopathology. 1991 Jan;18(1):73-7. doi: 10.1111/j.1365-2559.1991.tb00817.x.
The histological features in liver biopsy specimens from seven patients with acute exacerbation of chronic type B hepatitis were analysed. In all the cases typical changes of acute hepatitis were superimposed on signs of chronicity, namely peripheral piecemeal necrosis, plasma cell infiltration and porto-portal bridges, which in three cases contained elastic fibres. Reactivation of silent hepatitis B virus chronic infection should be considered as a possible diagnosis in any patient with histological findings of acute and chronic hepatitis.
对7例慢性乙型肝炎急性加重患者肝活检标本的组织学特征进行了分析。在所有病例中，急性肝炎的典型变化叠加在慢性病变的征象上，即周边性碎屑样坏死、浆细胞浸润和汇管区-汇管区桥接，其中3例含有弹性纤维。对于任何具有急性和慢性肝炎组织学表现的患者，应考虑隐匿性乙型肝炎病毒慢性感染再激活作为一种可能的诊断。
