Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Arch Gynecol Obstet. 2011 Mar;283(3):449-53. doi: 10.1007/s00404-010-1375-7. Epub 2010 Feb 5.
To create a nomogram for fetal splenic circumference of normal fetuses.
A prospective, cross-sectional study was undertaken on normal pregnancies with certain date from 14 to 40 weeks of gestation. All fetuses were measured for fetal splenic circumference by tracing technique on transverse view of the fetal abdomen, using high-resolution real-time ultrasound with a 2-4 MHz convex transducer.
A total of 684 normal pregnant women between 14 and 40 weeks of gestation were recruited. Fifty-eight were excluded because of poor image quality and fetal abnormality. The remaining 626 were available for analysis. Quadratic equation model was best fitted to estimate the 5th, 50th and 95th percentile range of splenic circumference at each gestational week. Fetal splenic circumference was gradually increased with gestational age with fitted equation as follows: splenic circumference (cm) = -4.181 + 0.456 (GA) -0.001 (GA)(2) (r = 0.942, p < 0.001). The table of nomogram for various percentile ranges was constructed.
A normal reference range of fetal splenic circumference for each week of gestational age during 14-40 weeks is established.
建立正常胎儿脾围的诺模图。
本前瞻性、横断面研究纳入了妊娠 14 周至 40 周且具有特定胎龄的正常孕妇。所有胎儿均在胎儿腹部横切面采用高分辨率实时超声和 2-4MHz 凸阵探头通过描绘技术测量脾围。
共纳入 684 名妊娠 14 周至 40 周的正常孕妇。58 名孕妇因图像质量差和胎儿异常被排除。其余 626 名孕妇可用于分析。二次方程模型最适合估计每个孕周脾围的第 5、50 和 95 百分位范围。脾围随胎龄逐渐增加，拟合方程为：脾围（cm）=-4.181+0.456（GA）-0.001（GA）^2（r=0.942，p<0.001）。构建了各种百分位范围的诺模图表。
建立了妊娠 14 周至 40 周各周龄正常胎儿脾围的参考范围。
