MacDonald T T, Choy M Y, Spencer J, Richman P I, Diss T, Hanchard B, Venugopal S, Bundy D A, Cooper E S
Department of Paediatric Gastroenterology, St Bartholomew's Hospital, London.
J Clin Pathol. 1991 Mar;44(3):194-9. doi: 10.1136/jcp.44.3.194.
Caecal biopsy specimens from Jamaican children with the Trichuris dysentery syndrome (TDS) and age matched Jamaican controls were investigated by immunohistochemistry and by light microscopy. Biopsy specimens from all children (with TDS and controls) showed a mild to moderate increase in inflammatory cells. Except in the vicinity of the worm, where the epithelium was flattened, there was no other epithelial abnormality. Compared with controls, children with TDS had increased IgM lamina propria plasma cells and decreased intraepithelial T cells. There was also an increase in crypt epithelial cell proliferation. Lamina propria T cells (both activated and non-activated) were no more common in children with the Trichuris syndrome than controls. Epithelial cell HLA-DR and VLA-1 expression (which are increased in other colitides) were the same in both groups. Despite the presence of large worm burdens and chronic dysentery, therefore, only minor changes were seen in the caecal mucosa of children with TDS.
采用免疫组织化学和光学显微镜检查，对患有鞭虫痢疾综合征（TDS）的牙买加儿童及年龄匹配的牙买加对照儿童的盲肠活检标本进行了研究。所有儿童（TDS患儿和对照儿童）的活检标本均显示炎症细胞有轻度至中度增加。除了在虫体附近上皮细胞扁平外，没有其他上皮异常。与对照相比，TDS患儿固有层IgM浆细胞增加，上皮内T细胞减少。隐窝上皮细胞增殖也增加。鞭虫综合征患儿固有层T细胞（活化和未活化）并不比对照儿童更常见。两组上皮细胞HLA-DR和VLA-1表达（在其他结肠炎中增加）相同。因此，尽管存在大量虫负荷和慢性痢疾，但TDS患儿的盲肠黏膜仅出现轻微变化。
