MacDonald T T, Spencer J, Murch S H, Choy M Y, Venugopal S, Bundy D A, Cooper E S
Department of Paediatric Gastroenterology, St Bartholomew's Hospital, London, UK.
Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):265-8. doi: 10.1016/0035-9203(94)90072-8.
Mucosal macrophages and accessory cells have been studied by immunohistochemistry in the lamina propria of the colon of children with Trichuris trichiura dysentery syndrome (TDS). No difference was found in the numbers of cells recognized by the monoclonal antibodies CD11c, CD68, or RFD7 between TDS children and local controls. However, large numbers of cells were recognized by an antibody against calprotectin (an anti-bacterial glycoprotein found in tissue infiltrating-monocytes) in TDS colonic mucosa, but few in control colon. Large numbers of cells containing tumour necrosis factor alpha (TNF alpha) were also seen in TDS mucosa; cells isolated from TDS mucosa secreted more TNF alpha than cells from control mucosa; and children with TDS had high levels of circulating TNF alpha. Non-specific macrophage-mediated inflammation and local cytokine production may therefore play a role in the pathogenesis of TDS.
采用免疫组织化学方法，对鞭虫痢疾综合征（TDS）患儿结肠固有层中的黏膜巨噬细胞和辅助细胞进行了研究。TDS患儿与本地对照者之间，单克隆抗体CD11c、CD68或RFD7识别的细胞数量未发现差异。然而，TDS结肠黏膜中有大量细胞被抗钙卫蛋白抗体（一种在组织浸润单核细胞中发现的抗菌糖蛋白）识别，而对照结肠中则很少。TDS黏膜中也可见大量含有肿瘤坏死因子α（TNFα）的细胞；从TDS黏膜分离的细胞比对照黏膜的细胞分泌更多的TNFα；TDS患儿循环中的TNFα水平较高。因此，非特异性巨噬细胞介导的炎症和局部细胞因子产生可能在TDS的发病机制中起作用。
