Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-6070, USA.
Trends Cell Biol. 2010 Apr;20(4):214-22. doi: 10.1016/j.tcb.2010.01.003.
The large nuclear mitotic apparatus (NuMA) protein is an abundant component of interphase nuclei and an essential player in mitotic spindle assembly and maintenance. With its partner, cytoplasmic dynein, NuMA uses its cross-linking properties to tether microtubules to spindle poles. NuMA and its invertebrate homologs play a similar tethering role at the cell cortex, thereby mediating essential asymmetric divisions during development. Despite its maintenance as a nuclear component for decades after the final mitosis of many cell types (including neurons), an interphase role for NuMA remains to be established, although its structural properties implicate it as a component of a nuclear scaffold, perhaps as a central constituent of the proposed nuclear matrix.
大型核有丝分裂装置（NuMA）蛋白是间期核的丰富成分，是有丝分裂纺锤体组装和维持的重要参与者。NuMA 与其伴侣细胞质动力蛋白一起，利用其交联特性将微管固定到纺锤体两极。NuMA 及其无脊椎动物同源物在细胞皮层中发挥类似的固定作用，从而在发育过程中介导必需的不对称分裂。尽管在许多细胞类型（包括神经元）的最后一次有丝分裂后几十年，NuMA 仍作为核成分得以维持，但它在间期的作用仍有待确定，尽管其结构特性表明它是核支架的一个组成部分，也许是拟议核基质的核心成分。
