骨生成中的粘着斑。
Focal adhesions in osteoneogenesis.
作者信息
Biggs M J P, Dalby M J
机构信息
Nanotechnology Center for Mechanics in Regenerative Medicine, Department of Applied Physics and Applied Mathematics, Columbia University, New York 10027, USA.
出版信息
Proc Inst Mech Eng H. 2010 Dec;224(12):1441-53. doi: 10.1243/09544119JEIM775.
Abstract
As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material surface or chemical stimuli in order to help to develop next-generation biomaterials. The focus of this review is on recent studies and developments concerning focal adhesion formation in osteoneogenesis, with an emphasis on the influence of synthetic constructs on integrin-mediated cellular adhesion and function.
摘要
随着材料技术和组织工程领域的发展，细胞黏附机制的作用，尤其是与可植入装置的相互作用，在研究和临床实践中变得越发重要。医疗设备技术的一个关键原则是利用生物系统对材料表面或化学刺激做出反应的精湛能力，以助力开发下一代生物材料。本综述的重点是关于骨生成中黏着斑形成的最新研究和进展，着重于合成构建体对整合素介导的细胞黏附和功能的影响。
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1
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J Biol Chem. 2010 Jan 1;285(1):30-42. doi: 10.1074/jbc.M109.010512. Epub 2009 Nov 4.
2
Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis.激活整合素α5可促进人间充质干细胞向成骨细胞分化及骨生成。
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18587-91. doi: 10.1073/pnas.0812334106. Epub 2009 Oct 20.
3
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction.α(5)β(1)整合素的聚集决定黏附强度，而α(v)β(3)和踝蛋白则促成机械转导。
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16245-50. doi: 10.1073/pnas.0902818106. Epub 2009 Sep 3.
4
Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.Runx2转录因子中ERK/MAPK磷酸化位点的鉴定及功能表征
J Biol Chem. 2009 Nov 20;284(47):32533-43. doi: 10.1074/jbc.M109.040980. Epub 2009 Sep 30.
5
Integrins.整合素。
Cell Tissue Res. 2010 Jan;339(1):269-80. doi: 10.1007/s00441-009-0834-6. Epub 2009 Aug 20.
6
Demonstration of catch bonds between an integrin and its ligand.整合素与其配体之间捕获键的证明。
J Cell Biol. 2009 Jun 29;185(7):1275-84. doi: 10.1083/jcb.200810002.
7
The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells.利用纳米级形貌调控原代成骨细胞中黏附形成的动力学以及富含STRO-1的骨骼干细胞中的ERK/MAPK信号传导。
Biomaterials. 2009 Oct;30(28):5094-103. doi: 10.1016/j.biomaterials.2009.05.049. Epub 2009 Jun 21.
8
The effects of implant surface nanoscale features on osteoblast-specific gene expression.植入物表面纳米级特征对成骨细胞特异性基因表达的影响。
Biomaterials. 2009 Sep;30(25):4053-62. doi: 10.1016/j.biomaterials.2009.04.010. Epub 2009 May 21.
9
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?细胞外信号调节激酶1/2（ERK1/2）的激活如何控制细胞增殖和细胞死亡：亚细胞定位是答案吗？
Cell Cycle. 2009 Apr 15;8(8):1168-75. doi: 10.4161/cc.8.8.8147. Epub 2009 Apr 11.
10
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J Cell Biochem. 2009 May 15;107(2):224-32. doi: 10.1002/jcb.22118.
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