Biggs M J P, Dalby M J
Nanotechnology Center for Mechanics in Regenerative Medicine, Department of Applied Physics and Applied Mathematics, Columbia University, New York 10027, USA.
Proc Inst Mech Eng H. 2010 Dec;224(12):1441-53. doi: 10.1243/09544119JEIM775.
As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material surface or chemical stimuli in order to help to develop next-generation biomaterials. The focus of this review is on recent studies and developments concerning focal adhesion formation in osteoneogenesis, with an emphasis on the influence of synthetic constructs on integrin-mediated cellular adhesion and function.
随着材料技术和组织工程领域的发展,细胞黏附机制的作用,尤其是与可植入装置的相互作用,在研究和临床实践中变得越发重要。医疗设备技术的一个关键原则是利用生物系统对材料表面或化学刺激做出反应的精湛能力,以助力开发下一代生物材料。本综述的重点是关于骨生成中黏着斑形成的最新研究和进展,着重于合成构建体对整合素介导的细胞黏附和功能的影响。