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含烷硫基甲基和烷氧基甲基疏水基团的氯化吡啶鎓的合成及其杀菌性能

Synthesis and bactericidal properties of pyridinium chlorides with alkylthiomethyl and alkoxymethyl hydrophobic groups.

作者信息

Weglewski J, Pernak J, Krysinski J

机构信息

Technical University of Poznań, Institute of Chemical and Engineering Technology, Poland.

出版信息

J Pharm Sci. 1991 Jan;80(1):91-5. doi: 10.1002/jps.2600800122.

DOI:10.1002/jps.2600800122
PMID:2013858
Abstract

The products of a reaction between 3-ethoxymethylpyridine and chloromethylalkyl ether or sulfide were proven to be 1-[(alkylthio)-methyl]-3-[(ethoxy)methyl]pyridinium or 1-[(alkoxy)methyl]-3-[(ethoxy)-methyl]pyridinium chlorides. Bacteriostatic properties of the obtained chlorides against 13 different microbial strains representing cocci, rods, fungi, and bacilli were studied. The MICs were measured by serial dilution. All studied chlorides showed bacteriostatic properties. Particularly high activity against microbes was shown by 1-[(dodecylthio)-methyl]-3-[(ethoxy)methyl]pyridinium and 3-[(ethoxy)methyl]-1-[(tetradecylthio)methyl]pyridinium chlorides.

摘要

已证实3-乙氧基甲基吡啶与氯甲基烷基醚或硫化物反应的产物为1-[(烷硫基)甲基]-3-[(乙氧基)甲基]吡啶鎓氯化物或1-[(烷氧基)甲基]-3-[(乙氧基)甲基]吡啶鎓氯化物。研究了所得氯化物对代表球菌、杆菌、真菌和芽孢杆菌的13种不同微生物菌株的抑菌特性。通过连续稀释法测量最低抑菌浓度（MIC）。所有研究的氯化物均显示出抑菌特性。1-[(十二烷基硫基)甲基]-3-[(乙氧基)甲基]吡啶鎓氯化物和3-[(乙氧基)甲基]-1-[(十四烷基硫基)甲基]吡啶鎓氯化物对微生物表现出特别高的活性。

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