Pernak J, Kalewska J, Ksycińska H, Cybulski J
Poznań University of Technology, Skłodowskiej-Curie 2, 60-965 Poznań, Poland.
Eur J Med Chem. 2001 Nov-Dec;36(11-12):899-907.
A novel class of functionalized cationic surfactant has been obtained. The work-up procedure of synthesis is very simple, the yield is high and the pyridinium salts with alkoxymethyl hydrophobic group are easily purified. All the salts examined showed anti-microbial activities. Some of them exhibited strong activity and wide anti-bacterial spectra similar to the activity of benzalkonium chloride. The relationship between chemical structure and anti-microbial activity was analysed by the QSAR method.
已获得一类新型的功能化阳离子表面活性剂。合成的后处理程序非常简单，产率高，且带有烷氧基甲基疏水基团的吡啶鎓盐易于纯化。所有检测的盐均显示出抗菌活性。其中一些表现出强活性和类似于苯扎氯铵活性的广泛抗菌谱。通过定量构效关系（QSAR）方法分析了化学结构与抗菌活性之间的关系。
