Kim Jae Kyeom, Choi Soo Jung, Cho Hong Yon, Hwang Han-Joon, Kim Young Jun, Lim Seung Taik, Kim Chang-Ju, Kim Hye Kyung, Peterson Sabrina, Shin Dong-Hoon
Department of Food and Biotechnology, Korea University, Seoul, Republic of Korea.
Biosci Biotechnol Biochem. 2010;74(2):397-401. doi: 10.1271/bbb.90585. Epub 2010 Feb 7.
To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Abeta)-induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.
为了确定山奈酚的作用，将大鼠嗜铬细胞瘤细胞（PC12）和癌症研究所（ICR）小鼠用作神经元模型。通过体外试验表明，山奈酚对PC12细胞中氧化应激诱导的细胞毒性具有保护作用。给予山奈酚还显著逆转了淀粉样β肽（Aβ）诱导的Y迷宫试验中的行为障碍。综上所述，此处报道的结果表明有必要进一步研究山奈酚对与阿尔茨海默病相关通路的影响。
