Center of Infectious Diseases, Federal University of Espírito Santo, Avenida Marechal Campos 1468, Maruípe, Vitória, ES.
Braz J Infect Dis. 2009 Apr;13(2):137-41. doi: 10.1590/s1413-86702009000200013.
This study evaluated differences in AIDS patients with and without tuberculosis (TB) in Espírito Santo State, Brazil. Standard regional AIDS (SINAN, SISCEL, SICLOM and SIM) and tuberculosis (SINAN) databases were used. TB and AIDS databases were linked using Reclink software, version 3, with SPSS software support to identify co-infected cases. Data from July 2000 to June 2006 in Espírito Santo State were linked. The results showed 3,523 adult AIDS cases and 9,958 adult TB cases resulted in 430 co-infected patients, who were compared to 1,290 AIDS patients who never developed TB. Among 430 co-infected patients, TB was diagnosed first in 223 (51.9%), AIDS was first in 44 (10.2%), and AIDS and TB were diagnosed concurrently in 163 (37.9%). Median age did not differ between co-infected cases (36 years (interquartile range [IQR] 29-43) and non-co-infected cases (34 years; IQR 28-42). Pulmonary tuberculosis was diagnosed in 239 (55.6%); 109 (25.3%) had extra-pulmonary TB and 82 (19.1%) had both presentations. In the final logistic regression model, living in a metropolitan area [Odds Ratio (OR)=1.43 (95% Confidence Interval (CI) 1.05-1.95)], education < 3 years [OR=3.03 (95%CI 1.56-5.88)] and CD4 counts < 200/mm(3) [OR=1.14 (95%CI 1.09-1.18)] were associated with co-infection. This report emphasizes the significance of tuberculosis among AIDS cases in Brazil, and highlights the importance of evaluating secondary data for purposes of improving data quality and developing public health interventions.
本研究评估了巴西圣埃斯皮里图州艾滋病患者与结核病（TB）患者之间的差异。使用了标准区域艾滋病（SINAN、SISCEL、SICLOM 和 SIM）和结核病（SINAN）数据库。使用 Reclink 软件版本 3 将 TB 和艾滋病数据库链接，并使用 SPSS 软件支持来识别合并感染病例。对 2000 年 7 月至 2006 年 6 月期间在圣埃斯皮里图州的数据进行了链接。结果显示，3523 例成人艾滋病病例和 9958 例成人结核病病例导致 430 例合并感染患者，与从未发生结核病的 1290 例艾滋病患者进行了比较。在 430 例合并感染患者中，223 例（51.9%）首先诊断为结核病，44 例（10.2%）首先诊断为艾滋病，163 例（37.9%）同时诊断为艾滋病和结核病。合并感染病例和未合并感染病例的中位年龄无差异（36 岁（四分位距 [IQR] 29-43）和 34 岁（IQR 28-42）。诊断为肺结核的患者 239 例（55.6%），诊断为肺外结核的患者 109 例（25.3%），同时诊断为肺内和肺外结核的患者 82 例（19.1%）。在最终的逻辑回归模型中，生活在大都市地区[优势比（OR）=1.43（95%置信区间（CI）1.05-1.95]、受教育程度<3 年[OR=3.03（95%CI 1.56-5.88）]和 CD4 计数<200/mm3[OR=1.14（95%CI 1.09-1.18）]与合并感染相关。本报告强调了结核病在巴西艾滋病病例中的重要性，并突出了评估二级数据以提高数据质量和制定公共卫生干预措施的重要性。
