软饮料和果汁消费与胰腺癌风险：新加坡华人健康研究。
Soft drink and juice consumption and risk of pancreatic cancer: the Singapore Chinese Health Study.
机构信息
Cancer Control Program, Georgetown University Medical Center, Washington, District of Columbia, USA.
出版信息
Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):447-55. doi: 10.1158/1055-9965.EPI-09-0862.
BACKGROUND
Sugar-sweetened carbonated beverages (called soft drinks) and juices, which have a high glycemic load relative to other foods and beverages, have been hypothesized as pancreatic cancer risk factors. However, data thus far are scarce, especially from non-European descent populations. We investigated whether higher consumption of soft drinks and juice increases the risk of pancreatic cancer in Chinese men and women.
METHODS
A prospective cohort analysis was done to examine the association between soft drink and juice consumption and the risk of pancreatic cancer in 60,524 participants of the Singapore Chinese Health Study with up to 14 years of follow-up. Information on consumption of soft drinks, juice, and other dietary items, as well as lifestyle and environmental exposures, was collected through in-person interviews at recruitment. Pancreatic cancer cases and deaths were ascertained by record linkage of the cohort database with records of population-based Singapore Cancer Registry and the Singapore Registry of Births and Deaths.
RESULTS
The first 14 years for the cohort resulted in cumulative 648,387 person-years and 140 incident pancreatic cancer cases. Individuals consuming > or = 2 soft drinks/wk experienced a statistically significant increased risk of pancreatic cancer (hazard ratio, 1.87; 95% confidence interval, 1.10-3.15) compared with individuals who did not consume soft drinks after adjustment for potential confounders. There was no statistically significant association between juice consumption and risk of pancreatic cancer.
CONCLUSION
Regular consumption of soft drinks may play an independent role in the development of pancreatic cancer.
背景
含糖碳酸饮料（称为软饮料）和果汁的血糖生成负荷相对其他食物和饮料较高，被认为是胰腺癌的危险因素。然而，迄今为止的数据仍然很少，尤其是来自非欧洲血统人群的数据。我们研究了饮用更多软饮料和果汁是否会增加中国男性和女性患胰腺癌的风险。
方法
我们进行了一项前瞻性队列分析，以研究 60524 名新加坡华人健康研究参与者中软饮料和果汁消费与胰腺癌风险之间的关系，这些参与者的随访时间长达 14 年。通过在招募时的面对面访谈，收集了关于软饮料、果汁和其他饮食项目的消费以及生活方式和环境暴露的信息。通过队列数据库与基于人群的新加坡癌症登记处和新加坡出生和死亡登记处的记录链接，确定了胰腺癌病例和死亡。
结果
该队列的前 14 年累计了 60524 名参与者的 648387 人年和 140 例胰腺癌病例。与不饮用软饮料的人相比，每周饮用> = 2 份软饮料的人患胰腺癌的风险显著增加（风险比，1.87；95%置信区间，1.10-3.15），校正了潜在混杂因素后。果汁消费与胰腺癌风险之间没有统计学上显著的关联。
结论
经常饮用软饮料可能在胰腺癌的发展中起独立作用。
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