Omoti Afekhide E, Enock Malachi E, Okeigbemen Valentina W, Akpe Benedicta A, Fuh Ukamaka C
Department of Ophthalmology, University of Benin Teaching Hospital, P.M.B 1111, Benin City, Nigeria.
Middle East Afr J Ophthalmol. 2009 Jul;16(3):146-50. doi: 10.4103/0974-9233.56229.
The exact patho physiological mechanizm of optic nerve damage in glaucoma is not fully understood.
To assess the vascular risk factors in open angle glaucoma in African eyes.
Prospective multicenter hospital-based study in Edo State, Nigeria.
Three hundred and twenty-two glaucoma patients and 184 control subjects were included in the study comprising 200 male glaucoma patients (62.11%) and 122 females (37.89%). A cohort of consecutive patients with a diagnosis of primary open angle glaucoma and age and sex matched control subjects were included in this prospective, cross-sectional, and multicenter hospital-based study conducted during the period January-June 2008. Blood pressure (BP), pulse and intraocular pressure findings were recorded and mean BP, pulse and perfusion pressure for each eye calculated.
Mean, standard deviations, 95% confidence intervals, Welch's t test, and Fisher's exact test were calculated.
The mean IOP in the 644 eyes of the 322 glaucoma patients was 22.65 mmHg (SD plus/minus 11.06). The systolic blood pressure (P < 0.0001), diastolic blood pressure (P < 0.0001), mean arterial blood pressure (P < 0.0001), pulse pressure (P < 0.01), systolic perfusion pressure (P < 0.01) were all significantly higher in glaucoma patients than in control.
Higher systolic, diastolic, mean arterial BP and pulse pressure was found in Black African patients with open angle glaucoma.
青光眼视神经损伤的确切病理生理机制尚未完全明了。
评估非洲人眼中开角型青光眼的血管危险因素。
在尼日利亚江户州进行的一项基于医院的前瞻性多中心研究。
该研究纳入了322例青光眼患者和184例对照受试者，其中包括200例男性青光眼患者（62.11%）和122例女性患者（37.89%）。在2008年1月至6月期间进行的这项前瞻性、横断面、多中心医院研究中，纳入了一组连续的原发性开角型青光眼患者以及年龄和性别匹配的对照受试者。记录血压（BP）、脉搏和眼压测量结果，并计算每只眼睛的平均血压、脉搏和灌注压。
计算均值、标准差、95%置信区间、韦尔奇t检验和费舍尔精确检验。
322例青光眼患者的644只眼中，平均眼压为22.65 mmHg（标准差±11.06）。青光眼患者的收缩压（P<0.0001）、舒张压（P<0.0001）、平均动脉血压（P<0.0001）、脉压（P<0.01）、收缩期灌注压（P<0.01）均显著高于对照组。
在患有开角型青光眼的非洲黑人患者中发现收缩压、舒张压、平均动脉血压和脉压较高。
