Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, Jiangsu, China.
Viruses. 2019 Nov 7;11(11):1035. doi: 10.3390/v11111035.
Typical viral propagation involves sequential viral entry, uncoating, replication, gene transcription and protein synthesis, and virion assembly and release. Some viral proteins must be transported into host nucleus to facilitate viral propagation, which is essential for the production of mature virions. During the transport process, nuclear localization signals (NLSs) play an important role in guiding target proteins into nucleus through the nuclear pore. To date, some classical nuclear localization signals (cNLSs) and non-classical NLSs (ncNLSs) have been identified in a number of viral proteins. These proteins are involved in viral replication, expression regulation of viral genes and virion assembly. Moreover, other proteins are transported into nucleus with unknown mechanisms. This review highlights our current knowledge about the nuclear trafficking of cellular proteins associated with viral propagation.
典型的病毒繁殖过程包括病毒的连续进入、脱壳、复制、基因转录和蛋白质合成以及病毒粒子的组装和释放。一些病毒蛋白必须运输到宿主细胞核内，以促进病毒繁殖，这对成熟病毒粒子的产生至关重要。在运输过程中，核定位信号（NLS）在通过核孔引导靶蛋白进入细胞核中起着重要作用。迄今为止，已在许多病毒蛋白中鉴定出一些经典核定位信号（cNLS）和非经典 NLS（ncNLS）。这些蛋白参与病毒复制、病毒基因的表达调控和病毒粒子的组装。此外，还有其他一些蛋白以未知机制被运输到细胞核内。本文综述了与病毒繁殖相关的细胞蛋白的核转运的研究进展。
