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Diallyl trisulfide-induced apoptosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest.二烯丙基三硫化物诱导人癌细胞凋亡与检查点激酶1介导的有丝分裂停滞有关。
Mol Carcinog. 2009 Nov;48(11):1018-29. doi: 10.1002/mc.20553.
2
Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice.大蒜成分二烯丙基三硫化物可预防TRAMP小鼠低分化前列腺癌的发生及肺转移多样性。
Cancer Res. 2008 Nov 15;68(22):9503-11. doi: 10.1158/0008-5472.CAN-08-1677.
3
Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds.二烯丙基三硫醚及相关葱属蔬菜衍生的有机硫化合物对癌症的多靶点预防与治疗
Cancer Lett. 2008 Oct 8;269(2):305-14. doi: 10.1016/j.canlet.2008.05.027. Epub 2008 Jun 24.
4
Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak.二烯丙基三硫通过线粒体介导人前列腺癌细胞凋亡，这与活性氧的产生有关，并受Bax/Bak调控。
Mol Cancer Ther. 2007 May;6(5):1599-609. doi: 10.1158/1535-7163.MCT-06-0754.
5
Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic.二烯丙基三硫醚（一种加工大蒜中有前景的癌症化学预防成分）激活癌细胞中一种新的共济失调毛细血管扩张症突变型和Rad3相关/检查点激酶1依赖性的前中期检查点。
Mol Cancer Ther. 2007 Apr;6(4):1249-61. doi: 10.1158/1535-7163.MCT-06-0477. Epub 2007 Apr 3.
6
Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction.二烯丙基三硫化物通过诱导Bax和Bak，在体内抑制PC-3人前列腺癌异种移植瘤的生长。
Clin Cancer Res. 2006 Nov 15;12(22):6836-43. doi: 10.1158/1078-0432.CCR-06-1273.
7
c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells.c-Jun氨基末端激酶信号轴调节二烯丙基三硫化物诱导的人前列腺癌细胞中活性氧的产生和细胞周期停滞。
Cancer Res. 2006 May 15;66(10):5379-86. doi: 10.1158/0008-5472.CAN-06-0356.
8
Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin.二烯丙基三硫醚通过对β-微管蛋白的氧化修饰抑制人结肠癌细胞的增殖并诱导其凋亡。
J Biol Chem. 2005 Dec 16;280(50):41487-93. doi: 10.1074/jbc.M507127200. Epub 2005 Oct 11.
9
Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells.二烯丙基三硫化物是加工大蒜的一种成分，它可使Akt失活，从而引发BAD的线粒体易位以及半胱天冬酶介导的人前列腺癌细胞凋亡。
Carcinogenesis. 2006 Mar;27(3):533-40. doi: 10.1093/carcin/bgi228. Epub 2005 Sep 16.
10
Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells.关卡激酶1调节二烯丙基三硫化物诱导的人前列腺癌细胞有丝分裂停滞。
J Biol Chem. 2005 Aug 5;280(31):28519-28. doi: 10.1074/jbc.M501443200. Epub 2005 Jun 16.

二烯丙基三硫诱导 DU145 细胞 G2/M 期细胞周期停滞与细胞周期蛋白依赖性激酶 1 的核转位延迟有关。

Diallyl trisulfide-induced G2/M phase cell cycle arrest in DU145 cells is associated with delayed nuclear translocation of cyclin-dependent kinase 1.

机构信息

Department of Pharmacology & Chemical Biology University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA.

出版信息

Pharm Res. 2010 Jun;27(6):1072-9. doi: 10.1007/s11095-010-0060-7. Epub 2010 Feb 9.

DOI:10.1007/s11095-010-0060-7
PMID:20143254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2873064/
Abstract

PURPOSE

The present study was undertaken to gain insight into the molecular mechanism of G2/M phase cell cycle arrest resulting from treatment of DU145 cells with diallyl trisulfide (DATS), a promising cancer chemopreventive constituent of garlic.

METHODS

Cell cycle distribution was determined by flow cytometry. Immunoblotting was performed to determine protein expression. Overexpression of wild-type or mutant Cdc25C was achieved by transient transfection. Nuclear and cytoplasmic localization of cyclin B1 and cyclin-dependent kinase 1 (cdk1) was studied by immunoblotting.

RESULTS

Exposure of DU145 human prostate cancer cells to DATS resulted in concentration- and time-dependent accumulation of G2/M phase cells, which correlated with down-regulation as well as increased S216 phosphorylation of Cdc25C. Ectopic expression of wild-type or redox-insensitive mutants (C330S and C330S/C377S) or S216A mutant of Cdc25C failed to confer protection against DATS-induced G2/M phase arrest. The DATS-mediated G2/M phase cell cycle arrest was also independent of reduced complex formation between cdk1 and cyclin B1, but correlated with delayed nuclear translocation of cdk1.

CONCLUSION

The present study indicates that the DATS-mediated G2/M phase cell cycle arrest in DU145 cells results from differential kinetics of nuclear localization of cdk1 and cyclin B1.

摘要

目的

本研究旨在深入了解二烯丙基三硫（DATS）诱导 DU145 细胞 G2/M 期细胞周期阻滞的分子机制，DATS 是大蒜中具有前景的癌症化学预防成分。

方法

通过流式细胞术测定细胞周期分布。通过免疫印迹法测定蛋白表达。通过瞬时转染实现野生型或突变型 Cdc25C 的过表达。通过免疫印迹法研究细胞周期蛋白 B1 和细胞周期蛋白依赖性激酶 1（cdk1）的核质定位。

结果

DATS 暴露于 DU145 人前列腺癌细胞中导致 G2/M 期细胞的浓度和时间依赖性积累，这与 Cdc25C 的下调以及 S216 磷酸化增加相关。野生型或氧化还原不敏感突变体（C330S 和 C330S/C377S）或 Cdc25C 的 S216A 突变体的异位表达不能赋予对 DATS 诱导的 G2/M 期细胞周期阻滞的保护作用。DATS 介导的 G2/M 期细胞周期阻滞也与 cdk1 和细胞周期蛋白 B1 之间形成复合物减少无关，但与 cdk1 的核易位延迟相关。

结论

本研究表明，DATS 诱导的 DU145 细胞 G2/M 期细胞周期阻滞是由于 cdk1 和细胞周期蛋白 B1 的核定位动力学不同所致。