National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.
Planta Med. 2010 Jul;76(10):1018-21. doi: 10.1055/s-0029-1240864. Epub 2010 Feb 8.
Phytochemical investigation of the leaves of Centella asiatica resulted in the isolation and characterization of eight triterpenes and/or saponins [which were characterized as 23- O-acetylmadecassoside (1), asiatic acid (2), madecassic acid (3), asiaticoside C (4), asiaticoside F (5), asiaticoside (6), madecassoside (7), and 23- O-acetylasiaticoside B (8)] together with sitosterol 3-O-beta-glucoside ( 9), stigmasterol 3- O- beta-glucoside (10), and querectin-3- O-beta-D-glucuronide (11). A new ursane-derived saponin (23- O-acetylmadecassoside) and a new oleanane-derived saponin (23- O-acetylasiaticoside B) were found as well. Structure elucidation was done by using spectroscopic techniques (HR-ESI-MS, 1D and 2D NMR), chemical methods, and comparative literature studies.
从积雪草的叶子中进行的植物化学研究，分离并鉴定了八种三萜和/或皂苷[被鉴定为 23-O-乙酰达玛甾苷（1）、积雪草酸（2）、麦角甾酸（3）、积雪草苷 C（4）、积雪草苷 F（5）、积雪草苷（6）、达玛甾苷（7）和 23-O-乙酰积雪草苷 B（8）]，以及β-谷甾醇葡萄糖苷（9）、β-谷甾醇葡萄糖苷（10）和槲皮素-3-O-β-D-葡萄糖醛酸苷（11）。还发现了一种新型的熊果酸衍生皂苷（23-O-乙酰达玛甾苷）和一种新型的齐墩果酸衍生皂苷（23-O-乙酰积雪草苷 B）。结构鉴定采用了光谱技术（高分辨电喷雾质谱、1D 和 2D NMR）、化学方法和文献比较研究。
