嗜碱性粒细胞在 Th2 反应起始中的作用。
Role of basophils in the initiation of Th2 responses.
机构信息
Department of Internal Medicine, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.
出版信息
Curr Opin Immunol. 2010 Feb;22(1):73-7. doi: 10.1016/j.coi.2010.01.012. Epub 2010 Feb 9.
Abstract
Long appreciated for their role as Type-2 effector cells, basophils have recently come into the spotlight for their role in the initiation of Type-2 immunity. Via an assortment of different activation pathways, basophils produce cytokines such as IL-4 that promote Th2 differentiation. Furthermore, recent studies using different experimental systems have shown that basophils can act as antigen presenting cells both in vitro and in vivo. In addition, basophils shape the Type-2 immune response by guiding antibody production and the memory response.
摘要
长期以来，嗜碱性粒细胞因其作为 2 型效应细胞的作用而备受关注，最近它们在启动 2 型免疫中的作用也引起了人们的关注。通过一系列不同的激活途径，嗜碱性粒细胞产生细胞因子，如 IL-4，促进 Th2 分化。此外，最近使用不同实验系统的研究表明，嗜碱性粒细胞可以在体外和体内作为抗原提呈细胞发挥作用。此外，嗜碱性粒细胞通过指导抗体产生和记忆反应来塑造 2 型免疫反应。
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