• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

关节软骨修复中软骨下骨的流行病学和影像学。

Epidemiology and imaging of the subchondral bone in articular cartilage repair.

机构信息

Unité d'orthopédie et traumatologie du sport, Service de chirurgie orthopédique et traumatologie de l'appareil moteur, University Hospital of Geneva, Genève, Switzerland.

出版信息

Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):463-71. doi: 10.1007/s00167-010-1053-0. Epub 2010 Feb 11.

DOI:10.1007/s00167-010-1053-0
PMID:20148327
Abstract

Articular cartilage and the subchondral bone act as a functional unit. Following trauma, osteochondritis dissecans, osteonecrosis or osteoarthritis, this intimate connection may become disrupted. Osteochondral defects-the type of defects that extend into the subchondral bone-account for about 5% of all articular cartilage lesions. They are very often caused by trauma, in about one-third of the cases by osteoarthritis and rarely by osteochondritis dissecans. Osteochondral defects are predominantly located on the medial femoral condyle and also on the patella. Frequently, they are associated with lesions of the menisci or the anterior cruciate ligament. Because of the close relationship between the articular cartilage and the subchondral bone, imaging of cartilage defects or cartilage repair should also focus on the subchondral bone. Magnetic resonance imaging is currently considered to be the key modality for the evaluation of cartilage and underlying subchondral bone. However, the choice of imaging technique also depends on the nature of the disease that caused the subchondral bone lesion. For example, radiography is still the golden standard for imaging features of osteoarthritis. Bone scintigraphy is one of the most valuable techniques for early diagnosis of spontaneous osteonecrosis about the knee. A CT scan is a useful technique to rule out a possible depression of the subchondral bone plate, whereas a CT arthrography is highly accurate to evaluate the stability of the osteochondral fragment in osteochondritis dissecans. Particularly for the problem of subchondral bone lesions, image evaluation methods need to be refined for adequate and reproducible analysis. This article highlights recent studies on the epidemiology and imaging of the subchondral bone, with an emphasis on magnetic resonance imaging.

摘要

关节软骨和软骨下骨作为一个功能单位。在创伤、剥脱性骨软骨炎、骨坏死或骨关节炎后,这种密切的联系可能会被打破。骨软骨缺损——即延伸至软骨下骨的类型的缺损——约占所有关节软骨病变的 5%。它们通常由创伤引起,约三分之一的病例由骨关节炎引起,很少由剥脱性骨软骨炎引起。骨软骨缺损主要位于股骨内侧髁和髌骨上。它们经常与半月板或前交叉韧带的损伤有关。由于关节软骨和软骨下骨之间的密切关系,软骨缺损或软骨修复的影像学检查也应侧重于软骨下骨。磁共振成像(MRI)目前被认为是评估软骨和软骨下骨的关键方式。然而,成像技术的选择也取决于导致软骨下骨病变的疾病性质。例如,X 线摄影仍然是评估骨关节炎特征的金标准。骨闪烁显像术是早期诊断膝关节自发性骨坏死的最有价值的技术之一。CT 扫描是排除软骨下骨板可能凹陷的有用技术,而 CT 关节造影术对评估剥脱性骨软骨炎中骨软骨碎片的稳定性非常准确。特别是对于软骨下骨病变的问题,需要改进图像评估方法,以便进行充分和可重复的分析。本文重点介绍了软骨下骨的流行病学和影像学研究的最新进展,强调了磁共振成像。

相似文献

1
Epidemiology and imaging of the subchondral bone in articular cartilage repair.关节软骨修复中软骨下骨的流行病学和影像学。
Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):463-71. doi: 10.1007/s00167-010-1053-0. Epub 2010 Feb 11.
2
Disease-specific clinical problems associated with the subchondral bone.与软骨下骨相关的特定疾病临床问题。
Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):448-62. doi: 10.1007/s00167-010-1052-1. Epub 2010 Feb 12.
3
The basic science of the subchondral bone.软骨下骨的基础科学。
Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):419-33. doi: 10.1007/s00167-010-1054-z. Epub 2010 Jan 30.
4
Osteochondral Lesions of the Knee: Differentiating the Most Common Entities at MRI.膝关节骨软骨病变:MRI 鉴别最常见病变。
Radiographics. 2018 Sep-Oct;38(5):1478-1495. doi: 10.1148/rg.2018180044. Epub 2018 Aug 17.
5
Clinical and Radiological Regeneration of Large and Deep Osteochondral Defects of the Knee by Bone Augmentation Combined With Matrix-Guided Autologous Chondrocyte Transplantation.通过骨增量联合基质引导自体软骨细胞移植实现膝关节大而深的骨软骨缺损的临床和影像学再生
Am J Sports Med. 2017 Nov;45(13):3069-3080. doi: 10.1177/0363546517717679. Epub 2017 Aug 4.
6
Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee.自体骨栓联合自体软骨细胞植入治疗膝关节骨软骨缺损
Am J Sports Med. 2016 May;44(5):1249-59. doi: 10.1177/0363546516631739. Epub 2016 Mar 10.
7
Results of arthroscopic fixation of osteochondritis dissecans lesion of the knee with cylindrical autogenous osteochondral plugs.膝关节剥脱性骨软骨炎病损采用圆柱状自体骨软骨栓行关节镜下固定的结果
Am J Sports Med. 2007 Feb;35(2):216-22. doi: 10.1177/0363546506294360. Epub 2006 Dec 27.
8
Review article: Osteochondral reconstruction and grafting.综述文章:骨软骨重建与移植
J Orthop Surg (Hong Kong). 2011 Apr;19(1):93-8. doi: 10.1177/230949901101900122.
9
Osteochondritis dissecans of the elbow: histopathological assessment of the articular cartilage and subchondral bone with emphasis on their damage and repair.肘关节剥脱性骨软骨炎:关节软骨和软骨下骨的组织病理学评估,重点关注其损伤与修复情况。
Pathol Int. 2006 Oct;56(10):604-12. doi: 10.1111/j.1440-1827.2006.02015.x.
10
[Osteochondritis dissecans of the femoral condyles: report of 892 cases].[股骨髁剥脱性骨软骨炎:892例报告]
Rev Chir Orthop Reparatrice Appar Mot. 2006 Sep;92(5 Suppl):2S97-2S141.

引用本文的文献

1
Conservative treatments of bone marrow lesions.骨髓病变的保守治疗。
J Exp Orthop. 2025 Apr 4;12(2):e70151. doi: 10.1002/jeo2.70151. eCollection 2025 Apr.
2
Advances in the Treatment of Partial-Thickness Cartilage Defect.治疗部分厚度软骨缺损的新进展。
Int J Nanomedicine. 2022 Dec 13;17:6275-6287. doi: 10.2147/IJN.S382737. eCollection 2022.
3
Knee osteochondritis dissecans-treatment technical aspects.膝关节剥脱性骨软骨炎——治疗技术要点

本文引用的文献

1
Positive effect of alendronate on subchondral bone healing and subsequent cartilage repair in a rabbit osteochondral defect model.阿伦膦酸盐对兔骨软骨缺损模型软骨下骨愈合及随后软骨修复的积极影响。
Am J Sports Med. 2009 Nov;37 Suppl 1:139S-47S. doi: 10.1177/0363546509350984.
2
Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study.软骨下骨髓病变与软骨下骨损耗具有高度相关性,并可进行纵向预测:MOST 研究。
Osteoarthritis Cartilage. 2010 Jan;18(1):47-53. doi: 10.1016/j.joca.2009.08.018. Epub 2009 Sep 10.
3
Contrast-enhanced MRI of subchondral cysts in patients with or at risk for knee osteoarthritis: the MOST study.
J Orthop. 2022 Aug 11;34:104-110. doi: 10.1016/j.jor.2022.08.005. eCollection 2022 Nov-Dec.
4
Porous 3D Scaffolds Enhance MSC Vitality and Reduce Osteoclast Activity.多孔 3D 支架可提高 MSC 活力并降低破骨细胞活性。
Molecules. 2021 Oct 16;26(20):6258. doi: 10.3390/molecules26206258.
5
Cyst formation in the subchondral bone following cartilage repair.软骨修复后软骨下骨囊肿形成。
Clin Transl Med. 2020 Dec;10(8):e248. doi: 10.1002/ctm2.248.
6
An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and osteochondral regeneration.一种用于顺序生物分子递送和骨软骨再生的全丝源功能性纳米球基质。
Bioact Mater. 2020 Jun 23;5(4):832-843. doi: 10.1016/j.bioactmat.2020.05.003. eCollection 2020 Dec.
7
Subchondral drilling for articular cartilage repair: a systematic review of translational research.软骨下钻孔术在关节软骨修复中的应用:转化研究的系统评价。
Dis Model Mech. 2018 Jun 19;11(6):dmm034280. doi: 10.1242/dmm.034280.
8
Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway.miR-195的减少通过靶向FGF-18途径促进软骨细胞增殖并维持软骨形成表型。
Int J Mol Sci. 2017 May 4;18(5):975. doi: 10.3390/ijms18050975.
9
Fluorescence molecular tomography of DiR-labeled mesenchymal stem cell implants for osteochondral defect repair in rabbit knees.用于兔膝关节骨软骨缺损修复的DiR标记间充质干细胞植入物的荧光分子断层成像
Eur Radiol. 2017 Mar;27(3):1105-1113. doi: 10.1007/s00330-016-4457-5. Epub 2016 Jun 21.
10
Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage.对比增强微计算机断层扫描评价马关节软骨自发性修复。
Cartilage. 2012 Jul;3(3):235-44. doi: 10.1177/1947603511424173.
膝关节骨关节炎患者或高危人群的软骨下囊肿的对比增强 MRI:MOST 研究。
Eur J Radiol. 2010 Jul;75(1):e92-6. doi: 10.1016/j.ejrad.2009.08.009. Epub 2009 Sep 19.
4
CT arthrography, MR arthrography, PET, and scintigraphy in osteoarthritis.骨关节炎的CT关节造影、MR关节造影、PET及闪烁扫描术
Radiol Clin North Am. 2009 Jul;47(4):595-615. doi: 10.1016/j.rcl.2009.04.005.
5
Osteochondral defect repair after implantation of biodegradable scaffolds: indirect magnetic resonance arthrography and histopathologic correlation.可生物降解支架植入后骨软骨缺损修复:间接磁共振关节造影与组织病理学相关性
Acta Radiol. 2009 Sep;50(7):765-74. doi: 10.1080/02841850902980272.
6
Subchondral fluid dynamics in a model of osteoarthritis: use of dynamic contrast-enhanced magnetic resonance imaging.骨关节炎模型中的软骨下液流动力学:动态对比增强磁共振成像的应用。
Osteoarthritis Cartilage. 2009 Oct;17(10):1350-5. doi: 10.1016/j.joca.2009.03.019. Epub 2009 Apr 17.
7
MRI evaluation of a new scaffold-based allogenic chondrocyte implantation for cartilage repair.MRI 评估新型基于支架的同种异体软骨细胞植入物修复软骨。
Eur J Radiol. 2010 Jul;75(1):72-81. doi: 10.1016/j.ejrad.2009.03.056. Epub 2009 Apr 28.
8
MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis.MRI 检测膝关节软骨下骨髓信号改变:术语、影像学表现、相关性及放射学鉴别诊断。
Osteoarthritis Cartilage. 2009 Sep;17(9):1115-31. doi: 10.1016/j.joca.2009.03.012. Epub 2009 Mar 31.
9
Can T2 relaxation values and color maps be used to detect chondral damage utilizing subchondral bone marrow edema as a marker?能否将T2弛豫值和彩色图谱用于以软骨下骨髓水肿为标志物来检测软骨损伤?
Skeletal Radiol. 2009 May;38(5):459-65. doi: 10.1007/s00256-008-0629-y. Epub 2008 Dec 17.
10
Effect of risedronate in a minipig cartilage defect model with allograft.利塞膦酸盐在同种异体移植小型猪软骨缺损模型中的作用。
J Orthop Res. 2009 Mar;27(3):360-5. doi: 10.1002/jor.20775.